关键词: 微米中药功能衬材, 骨折, 血清碱性磷酸酶, 血钙, 血磷

Abstract:

BACKGROUND: External preparations treatment of fractures in traditional Chinese medicine are mostly ordinary hard-paste, cream, ointment, which lack of modernized traditional Chinese medicine transdermal delivery systems, and the treatment has poor drug absorption and simple process. The treating procedure needs to be used repeatedly, which would affect fracture external fixation and lead to unsatisfactory therapeutic effect. In this paper, the external treatment of traditional Chinese medicine was combined with advanced micro-nano-technology to develop a new medical complex functional materials–micron traditional Chinese medicine functional lining material, which is an organic combination of diaplasis, fixation and local drug remedy, which provides a better treatment for fractures.
OBJECTIVE: To explore the effect of micron traditional Chinese medicine functional lining material on the healing of fracture in rabbits.
METHODS: After model preparation, rabbits were randomly divided into 4 groups: rabbits in the micron group were treated with micron traditional Chinese medicine functional lining material plus plaster external fixation; those in the traditional Chinese medicine control group were treated with ordinary Chinese medicine functional material plus plaster external fixation; those in the lining material control group were treated with ordinary lining material added plaster external fixation; those in the natural healing control group had no special treatments. The effect of fracture healing was evaluated by X-ray at 2, 4 and 6 weeks after modeling. The serum concentration of alkaline phosphatase, calcium and phosphorus was detected respectively before modeling and at 2, 4 and 6 weeks after modeling.
RESULTS AND CONCLUSION:  ①X-ray examination: After 6 weeks the external callus was almost completely absorbed and medullary cavity was completely recanalized in the micron group, while fracture line disappeared and the external callus began to be absorbed and medullary cavity was not recanalized in the traditional Chinese medicine control group. Additionally, there were cases of non-union stump hardening in natural healing group. ②Serum biochemistry: The activity of alkaline phosphatase reached a peak after 2 weeks in micron group, which was 2 weeks ahead of time compared with that in traditional Chinese medicine control group. And the peak concentration of alkaline phosphatase in micron group was higher than other groups. After 4 weeks serum calcium concentration started to fall significantly and phosphorus concentration started to rise significantly in micron group, as was statistically significant compared with other groups. After 6 weeks serum calcium concentration in micron group had fallen to normal level, while that in other groups was higher than normal. And phosphorus concentration in micron group increased significantly, which was statistically significant compared with natural healing group. The results demonstrated that micron feature traditional Chinese medicine lining material can enhance the activity of alkaline phosphatase, decrease the serum concentration of calcium and increase the serum concentration of phosphorus and the product of calcium and phosphorus, therefore, promote the healing of fracture. It shows that micron traditional Chinese medicine functional lining material plays a stronger effect on promoting the healing of fracture than that of ordinary Chinese medicine functional lining material.