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18 June 2013, Volume 17 Issue 25 Previous Issue    Next Issue

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Compound of porous hydroxyapatite, platelet-rich plasma and fibrin glue in the treatment of bone defects   Liu Dong-guang, Wei Zheng-chao, Cai Dao-zhang, Zheng Jun, Chen Huan-qiu, Lai Huan-le 2013, 17 (25):  4561-4569.  doi: 10.3969/j.issn.2095-4344.2013.25.001 Abstract ( 381 )   PDF (2668KB) ( 457 )   Save BACKGROUND: Autogenous bone graft is the best way to treat bone defects, but its limited sources and donor site complications restrain its clinical application. Therefore, to develop a substitute material has been a hotspot in the orthopedics. OBJECTIVE: To investigate the feasibility and effectiveness of the compound of coralline hydroxyapatite porous, platelet-rich plasma and fibrin glue acting as a bone substitute material for repair of bone defects. METHODS: 1.5 cm radial segments from the bilateral forearms of New Zealand white rabbits were removed to prepare bone defect models. Then, bone defect models were randomly divided into a compound group (coralline hydroxyapatite porous, platelet-rich plasma and fibrin glue), control group treated with autogenous bone graft, and blank group without implantation. RESULTS AND CONCLUSION: (1) X-ray observation: Bone defects were repaired completely in the compound group till the end of postoperative week 12, appearing with complete plasticity. The healing process in the compound group was synchronized with that in the control group. However, there were no changes in bone defects of the blank group. (2) Histopathological examination: Bone repair basically completed in the compound and control groups at week 12 after operation, presenting with mature lamellar bone and Haversian canals. In the blank group, only a great amount of fibroblasts proliferated, but no bone formed. (3) Biomechanical analysis: The maximum torque and torsional stiffness of the compound group were better than those of the control group at 2 weeks postoperation (P < 0.05). However, there was no significant difference between the maximum torque and torsional stiffness of the compound and control groups. These results demonstrate that the compound of coralline hydroxyapatite porous, platelet-rich plasma and fibrin glue acting as a bone substitute is superior to autologous bone in the early repair of bone defects, which is beneficial to bone healing. Figures and Tables | References | Related Articles | Metrics

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Endosseous implantation of calcium phosphate coated titanium implant prepared via micro-arc oxidation/electrochemical deposition   Ma Ying, Meng Xiang-cai, Wang Jing, Li De-chao 2013, 17 (25):  4570-4576.  doi: 10.3969/j.issn.2095-4344.2013.25.002 Abstract ( 477 )   PDF (2211KB) ( 508 )   Save BACKGROUND: There are studies concerning material properties of coating prepared by micro-arc oxidation and electrochemical deposition, but there are few studies addressing properties of this kind of material implanted in the body. OBJECTIVE: To observe the synostosis and new bone formation of the pure titanium implant prepared by micro-arc oxidation/electrochemical deposition. METHODS: This research produces calcium and phosphate coatings on pure titanium though micro-arc oxidation/Electrochemical deposition technology, and the sheep were implanted with micro arc-oxidation/electrochemical deposition implant and pure titanium implant on both sides of the tibia planting socket. All the animals were injected with tetracycline at 15 and 5 days before sacrificing. Radiograph, scanning electron microscope and the laser scanning confocal microscope were used at 4 and 12 weeks post-implantation. RESULTS AND CONCLUSION: The radiograph shows that there was no shade produced around the two kinds of different materials. The trabeculae arrangement and the density of bone were almost the same as in the host bone. There was interspace between two groups of implant and bone tissue under the scanning electron microscope at 4 weeks post-implantation, and synostosis existed. At 12 weeks post-implantation, the implant prepared by micro-arc oxidation/electrochemical deposition promoted the formation of new bone. Moreover, new bone and implant combined with the original bone tissue closely and there was no obvious gap between the coating and the titanium matrix. The new bone formation was visible in the pure titanium implant group at 12 weeks post-implantation, but the obvious crack was observed. The laser scanning confocal microscopy revealed that the double marking the distance between the belts and the bone mineralization deposition rate in the implant prepared by micro-arc oxidation/electrochemical deposition were higher than that in the pure titanium implant group (P < 0.05). These results indicated that micro-arc oxidation/electrochemical deposition can enhance the synostosis ability and promote the new bone formation of pure titanium implant. Figures and Tables | References | Related Articles | Metrics

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Drug loading of naringin nanofibrous membrane influences osteoblast proliferation and differentiation  Ji Yan, Wang Lu, You Tao, Wu Xiao-hong 2013, 17 (25):  4577-4584.  doi: 10.3969/j.issn.2095-4344.2013.25.003 Abstract ( 382 )   PDF (2803KB) ( 681 )   Save BACKGROUND: Guided bone regeneration membrane just plays a mechanical barrier and isolation effect, but cannot exert an active induction role. Numerous studies have shown that naringin can promote the proliferation and differentiation of a variety of osteoblast-like cells. OBJECTIVE: To prepare the guided bone regeneration membranes carrying naringin and to design the optimal drug loading of the membrane. METHODS: Nanofibrous membranes containing different contents of naringin (0, 0.1, 1, 10, 100 g/L) were prepared by electrospinning. The morphologies of the membranes were observed by scanning electron microscope. MC3T3-E1 osteoblasts were seeded on the membranes. The morphologies of the cell-membrane composites were observed by scanning electron microscope. The cell proliferation was tested by methyl thiazolyl tetrazolium assay and the cell differentiation was evaluated by alkaline phosphatase activity. RESULTS AND CONCLUSION: Smooth and uniform nanofibers were obtained by electrospinning with drug loading of 0.1, 1, 10 g/L naringin. There were no significant differences among the diameters of these three kinds of nanofibers. Many beads were observed in the nanofibrous membrane containing 100 g/L naringin. The results of methyl thiazolyl tetrazolium assay and alkaline phosphatase activity showed, as compared with the control group (containing 0 g/L naringin), the nanofibrous membrane containing 10 g/L naringin significantly promoted cell proliferation and differentiation (P < 0.05), while that containing 1 and 10 g/L naringin significantly increased alkaline phosphatase activity in osteoblasts (P < 0.05). The electrospinning naringin nanofibrous membrane with the optimal drug loading of 10 g/L promoted osteoblast proliferation and differentiation most significantly. Therefore, this new type of guided bone regeneration membranes will have a wonderful prospect in repair of bone defect under the state of osteoporosis. Figures and Tables | References | Related Articles | Metrics

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Open autologous minimal morselized bone grafting with vancomycin repairs infected tibial defects   Nan Chong, Jing Hao, Zhou Yue, Qiu Shao-dong, Bo Yu, Hu Ning-min 2013, 17 (25):  4585-4592.  doi: 10.3969/j.issn.2095-4344.2013.25.004 Abstract ( 360 )   PDF (736KB) ( 761 )   Save BACKGROUND: Studies have shown that 300-500 μm minimal morselized bone is easier than 4.0-5.0 mm morselized bone to survive in non-infected bone defects. OBJECTIVE: To investigate and evaluate the feasibility and clinical effect of open autologous minimal morselized bone grafting with vancomycin to treat infected tibial defects. METHODS: Twenty-eight patients with infected tibial defects or nonunion were treated with open autologous minimal morselized bone grafting, including 23 males and five females, aged from 9 to 58 years (average age of 35.2 years). There were 19 cases of upper tibial defects, two cases of middle tibial defects, and seven cases of distal tibial defects. After open fracture operation, there were 17 cases of postoperative infections and 11 cases of postoperative infection and bone nonunion. All the patients were followed up for 6-30 months for wound and fracture healing. RESULTS AND CONCLUSION: Transplanted minimal morselized bone was covered with granulation tissue after postoperative 6 weeks, and wound was completely closed after postoperative 8 weeks. Two cases of poor facture healing achieved bone healing after secondary bone graft. The mean healing duration was 5 months. No neurovascular injury and drug susceptibility reaction occurred. These findings indicate that open autologous minimal morselized bone grafting with vancomycin is feasible to treat infected tibial defects. Figures and Tables | References | Related Articles | Metrics

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Solid glass bead modified bisphenol A-glycidyl methacrylate resin composite as a filling material Meng Xiang-cai, Wang Jian-ping, He Mei-li 2013, 17 (25):  4593-4600.  doi: 10.3969/j.issn.2095-4344.2013.25.005 Abstract ( 427 )   PDF (1039KB) ( 551 )   Save BACKGROUND: Oral compound resin has high polymerization shrinkage rate and low mechanical strength that cannot meet the clinical requirements. OBJECTIVE: To investigate the ratio of bisphenol A-glycidyl methacrylate and triethylene glycol dimethacrylate as the resin matrix, and solid glass bead effects on flexural strength and polymerization shrinkage rate of oral composite resin. METHODS: Solid glass beads were siliconized by silane coupling agent KH-550. Solid glass beads at mass fraction of 10%, 30%, 50%, 70% and 90% were added into the oral composite resin containing bisphenol A-glycidyl methacrylate and triethylene glycol dimethacrylate at a ratio of 7/3, 6/4, and 5/5, respectively. After mechanical stirring, the mixture filled the mold for solidification. Non-solid glass bead resin served as control. Mechanical properties and shrinkage rate were analyzed. RESULTS AND CONCLUSION: With the increasing addition of solid glass beads, the flexural strength was increased first and then decreased, and polymerization shrinkage rate tended to be declined. The highest flexural strength was (88.29±0.66) MPa (P < 0.05), when bisphenol A-glycidyl methacrylate and triethylene glycol dimethacrylate were mixed at a ratio of 5/5 and the addition amount of solid glass beads was 70%. The minimal polymerization shrinkage rate was 0.898%, when bisphenol A-glycidyl methacrylate and triethylene glycol dimethacrylate were mixed at a ratio of 7/3 and the addition amount of solid glass beads was 70%. Figures and Tables | References | Related Articles | Metrics

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Wearing ability of zirconia and four kinds of full crown repair materials: Comparative study Wang Jun, Wang Ming-zhen, Wang Wan-chun, Yang Mei 2013, 17 (25):  4601-4608.  doi: 10.3969/j.issn.2095-4344.2013.25.006 Abstract ( 880 )   PDF (377KB) ( 571 )   Save BACKGROUND: Zirconia ceramics is a novel oral repair material in recent years, and it has welcomed by patients because of its aesthetics and biocompatibility, but the research on the wearing ability of zirconia ceramics on the jaw natural tooth is rare. OBJECTIVE: To observe the volume loss of zirconia ceramics and other four kinds of clinical commonly used full crown repair materials when grinding with steatite, and to compare with the natural tooth in order to research the wearing ability of zirconia and other repairing materials. METHODS: The zirconia ceramic, vita ceramics, gold-palladium alloy, nickel-chromium alloy, cobalt-chromium alloy and fresh natural enamel in the control group were installed in the upper fixture of wear machine respectively, and the steatite porcelain was installed in the lower fixture. Load abrasion tests were performed in artificial saliva environment, and then the volume loss of the materials in the upper and lower fixture was calculated; the hardness of the materials above was tested with fiber hardness testing machine; the specimen surface abrasion morphology was observed under scanning electron microscope. RESULTS AND CONCLUSION: The volume loss of the five materials when grinding with steatite was larger than that of the fresh natural enamel in the control group (P < 0.05); the hardness of zirconia ceramics was highest, and the volume loss of zirconia ceramics when grinding with steatite was largest. The gold-palladium alloy had the smallest hardness, and the volume loss of gold-palladium alloy when grinding with steatite was similar to that of the natural teeth; the hardness of all the materials was positively correlated with the volume loss of grinding steatite porcelain (P < 0.05). The zirconia ceramic and vita ceramic were mainly performed as abrasive wear, and the surface was in fissure protruding-like structure with deep abrasion furrows and irregular morphology, the scattered pore structure could be seen on the abrasion surface. The abrasion surface of cobalt-chromium alloy was relatively smooth with shallow abrasion furrows, and the scattered metal abrasive particles could be seen on the abrasion surface; deep and wide abrasion furrows and a large amount of metal abrasive particles could be seen on the abrasion surface of nickel-chromium alloy; abrasion furrows was evenly distributed on the abrasion surface of gold-palladium alloy, and the exfoliative plaque could be seen occasionally with metal abrasive particles in it. The results indicate that zirconia ceramic is likely to cause excessive abrasion on the jaw natural tooth in clinical application, so polishing should be performed before permanent cements; the gold-palladium alloy has the best wearing ability which is close to that of the natural teeth, and it is considered the better posterior region full crown repair material; the hardness of the dental prosthetic material can not represent the wearing ability, the microstructure of the material surface and other factors should be considered when using in order to play the advantages of various materials. Figures and Tables | References | Related Articles | Metrics

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Properties of nanometer silver antibacterial agent and tetrapod-like zinc oxide antibacterial agent against Candida albicans  Xiao Yue, Kang Liang, Lü Qing, Yu Bo-wen, Ma Ying-jun 2013, 17 (25):  4609-4615.  doi: 10.3969/j.issn.2095-4344.2013.25.007 Abstract ( 603 )   PDF (786KB) ( 664 )   Save BACKGROUND: Surface structure of room temperature curing methyl methacrylate is loose and porous, easy to be attached to a variety of bacteria, microbes, leading to the occurrence of denture stomatitis. Thus, antibacterial agent added in methyl methacrylate has been a hot focus in the study. OBJECTIVE: To compare the antibacterial activity of room temperature curing methyl methacrylate against Candida albicans after addition of the nanometer silver antibacterial agent and tetrapod-like zinc oxide antibacterial agent. METHODS: Minimum bactericidal concentration of nanometer silver antibacterial agent and tetrapod-like zinc oxide antibacterial agents against Candida albicans was determined by dilution method. The nanometer silver antibacterial agent loaded nanometer zirconium phosphate or tetrapod-like zinc oxide antibacterial agent with 0%, 1%, 2%, 3% mass fraction were added to the room temperature curing methyl methacrylate to detect the antibacterial property against Candida albicans. RESULTS AND CONCLUSION: The minimum bactericidal concentration of nanometer silver antibacterial agent was 40 g/L. The minimum bactericidal concentration of tetrapod-like zinc oxide agent against Candida albicans was 25 g/L. Methyl methacrylate without addition of nanometer silver antibacterial agent or tetrapod-like zinc oxide antibacterial agent did not have antibacterial activity, and the antibacterial activity significantly increased after addition of the two antibacterial agents. With the increased mass fraction of nanometer silver antibacterial agent or tetrapod-like zinc oxide antibacterial agent, the antibacterial properties of room temperature curing methyl methacrylate increased gradually. At 3% mass fraction, antibacterial rate of methyl methacrylate with nanometer silver antibacterial agent was 92.23%, and the antibacterial rate of methyl methacrylate with the tetrapod-like zinc oxide antibacterial agent was 98.23%. These results indicated that the nanometer silver antibacterial agent and tetrapod-like zinc oxide antibacterial agent have antibacterial effects against Candida albicans, and the tetrapod-like zinc oxide antibacterial agent has a good antibacterial effect compared with the nanometer silver antibacterial agent. Figures and Tables | References | Related Articles | Metrics

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Biocompatibility of human umbilical cord mesenchymal stem cells and acellular muscle bioscaffolds    Zhang Tao, Wen Yi-min, Li Han, Wei Xiang-ke 2013, 17 (25):  4616-4622.  doi: 10.3969/j.issn.2095-4344.2013.25.008 Abstract ( 307 )   PDF (864KB) ( 492 )   Save BACKGROUND: Acellular muscle bioscaffold combined with human umbilical cord mesenchymal stem cell transplantation is an important method for the treatment of spinal cord injury. But the compatibility between acellular muscle bioscaffolds and human umbilical cord mesenchymal stem cells, and whether the human umbilical cord mesenchymal stem cells can distribute evenly in the acellular muscle bioscaffolds have not been confirmed. OBJECTIVE: To observe the compatibility of acellular muscle bioscaffolds and human umbilical cord mesenchymal stem cells. METHODS: The rat acellular muscle bioscaffolds were prepared with improved chemical method, and the passage 3 human umbilical cord mesenchymal stem cells were divided into three groups after labeled with Hoechest33342: cell+scaffold group, cell+scaffold in vivo group and cell group. The morphology of the acellular muscle bioscaffolds was observed with hematoxylin-eosin staining and Masson staining, and the adsorption and growth conditions of human umbilical cord mesenchymal stem cells were observed under fluorescence inverted phase contrast microscope and scanning electron microscope. RESULTS AND CONCLUSION: The human umbilical cord mesenchymal stem cells were fully attached to and actively grew on the acellular muscle bioscaffold, and distributed evenly. There was no significant difference in the number of human umbilical cord mesenchymal stem cells between the cell+scaffold in vivo group and cell+scaffold group at 1-7 days after transplantation (P > 0.05). At the 14 days after transplantation, the number of human umbilical cord mesenchymal stem cells in the cell+scaffold in vivo group was larger than that in the cell+scaffold group (P < 0.05). There is a good compatibility between human umbilical cord mesenchymal stem cells and acellular muscle bioscaffold, and the in vivo environment is more conducive to cell proliferation and integration of cells and scaffolds. Figures and Tables | References | Related Articles | Metrics

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Biocompatibility of gatifloxacin-poly(sebacic anhydride) local control release system   Lu Feng, Zhang Hong-tu, Ma Shu-you 2013, 17 (25):  4623-4628.  doi: 10.3969/j.issn.2095-4344.2013.25.009 Abstract ( 450 )   PDF (661KB) ( 415 )   Save BACKGROUND: Polyanhydride material is characteristics of surface erosion, biodegradability and release rate adjustability, and it has been approved by the U.S. Food and Drug Administration for human drug carrier materials. OBJECTIVE: To prepare gatifloxa-poly(sebacic anhydride) local control release system and study its biocompatibility. METHODS: Poly(sebacic anhydride) was prepared with melt phase polycondensation method, and mixed with gatifloxacin in the agate mortar to make a local drug delivery system at 20% drug loading. Six rabbits were used to study the biocompatibility of poly(sebacic anhydride) and their back skin was cut open. Six rabbits were randomly divided into two groups, the experimental group was implanted with poly(sebacic anhydride) stick into the paraspinal muscle pouch, while the control group received no implants. Rabbits were killed at 5 weeks post-surgery, and changes on subcutaneous tissue and muscle tissue were observed, as well heart, liver, kidney, and lung.  RESULTS AND CONCLUSION: Poly(sebacic anhydride) has a good biocompatibility. After implantation, no rabbit appeared to have the change of appetite and behavior. There was no edema, hemorrhage and erosion at the implanted site, and the surface of implanted materials was porous, which suggested that the materials had been degraded and absorbed subcutaneously. In addition, embrittlement and disintegration were not observed; the implanted materials slightly adhered to surrounding tissue. There was no change in the liver, kidney, lung, heart and partial musculature. Gatifloxacin-poly(sebacic anhydride) local sustained release preparation is well histocompatible with no toxicity and teratogenic action. Figures and Tables | References | Related Articles | Metrics

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Combination of cryopreserved hydroxyapatite/bone marrow mesenchymal stem cells repairs rabbit radial defects Xing Zhi-yuan, Zhang Ji-bo, Kong Ling-ju, Liu Jian-sheng, Zheng De-yu 2013, 17 (25):  4629-4636.  doi: 10.3969/j.issn.2095-4344.2013.25.010 Abstract ( 266 )   PDF (2343KB) ( 484 )   Save BACKGROUND: Previous studies have showed that hydroxyapatite combined with bone marrow mesenchymal stem cells has a good effect on bone defects, but the repair effect of cryopreserved composite material is unclear. OBJECTIVE: To observe the effect of cryopreserved hydroxyapatite/bone marrow mesenchymal stem cells on bone defects. METHODS: Twenty-seven Japanese rabbits were used to prepare 10 mm radial defect models and then randomly divided into cryopreserved composite group, fresh composite group and hydroxyapatite group. The three groups were respectively implanted with cryopreserved hydroxyapatite/bone marrow mesenchymal stem cells which were cryopreserved at -80℃ for 3 months, fresh hydroxyapatite/bone marrow mesenchymal stem cells and pure hydroxyapatite. After 8 and 12 weeks, general observation, X-ray observation and hematoxylin-eosin staining were performed, and biomechanical test was done at 12 weeks. RESULTS AND CONCLUSION: At postoperative 12 weeks, bone defects were almost healed in the cryopreserved composite group and fresh composite group. Mature trabecular bone was seen, some canals were of patency, and good shape was found. While in the hydroxyapatite group, callus formation was less, only part of bone defects were healed, shaping was poor, and new bone formation was also less than the other two groups (P < 0.05). In addition, the maximal loading in the cryopreserved composite group and fresh composite group was significantly higher than that in the hydroxyapatite group (P < 0.05). These findings indicate that the cryopreserved hydroxyapatite/bone marrow mesenchymal stem cells composite material is similar to the fresh one in the repair capacity. Figures and Tables | References | Related Articles | Metrics

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Intramuscular transplantation of macroencapsulated islets for type 1 diabetes mellitus in mice Li Hui, Fu Hong-xing, Zhu Yan-lin, Li Xiao-kun 2013, 17 (25):  4637-4643.  doi: 10.3969/j.issn.2095-4344.2013.25.011 Abstract ( 259 )   PDF (2203KB) ( 531 )   Save BACKGROUND: Alginate-barium chloride microbeads confer immune isolation and prevent graft rejection in preliminary experiments. OBJECTIVE: To assess the role of alginate- barium chloride microbead encapsulation in the treatment of type 1 diabetes mellitus in mice. METHODS: The single islet cell group was isolated from the pancreas of Sprague-Dawley rats and purified. And cells were encapsulated into alginate-barium chloride microbeads. Type 1 diabetes mellitus was induced with streptozotocin into C57BL/6 mice via intraperitoneal injection, and randomly divided into four groups. The pure islets encapsulated in alginate-barium chloride microbeads were transplanted into the biceps femoris in the mice with type 1 diabetes mellitus, as experimental group. The pure islets were transplanted into diabetic recipients at biceps femoris, as control group. Normal C57BL/6 mice were injected with saline into biceps femoris, as normal control group. Diabetic C57BL/6 mice were injected with saline into biceps femoris, as diabetes control group. Then the blood glucose levels and macroencapsulated islets at the transplantation site were observed. RESULTS AND CONCLUSION: After isolation and purification, (905.4±34.5) islets per mouse were obtained and possessed excellent activity. Duration of normal blood glucose after operation in experimental group was approximately 6.3 days. The islet graft survival duration was longer than 30 days. The blood glucose levels in control group were not recovered to normal, and the islet graft survival duration was 4 days. The glucose-lowering rate in experimental group was significantly faster than that in control group and diabetes control group (P < 0.05). Experimental findings indicate that, islets encapsulated in alginate-barium chloride microbeads could survive in the muscles and treat type 1 diabetes mellitus. Figures and Tables | References | Related Articles | Metrics

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Galactosylated alginate and sodium alginate: What is the optimal mass ratio for maintaining the mechanical stability?   Tian Meng, Han Bo, You Chao, Wan Chang-xiu 2013, 17 (25):  4644-4651.  doi: 10.3969/j.issn.2095-4344.2013.25.012 Abstract ( 423 )   PDF (973KB) ( 576 )   Save BACKGROUND: Numerous studies showed that material surface modified with galactose can improve adhesion of hepatocytes, and then affect morphology and functional expression of hepatocytes. Microcapsule prepared by electrostatic complex has been widely used in cell encapsulation, enzyme immobilization, drug controlled release and etc. However, there is no report on hepatocytes encapsulated into the microcapsule prepared with chitosan oligomer and alginate sodium. OBJECTIVE: To prepare a novel galactosylated alginate-chitosan oligomer microcapsule for hepatocytes encapsulation. METHODS: The synthesized galactosylated alginate was characterized with Fourier transform infrared spectra, nuclear magnetic resonance spectroscopy, and elemental analysis. The solubility of chitosan oligomer was studied by turbidimetric method. The effect of preparation conditions on the microcapsule was finally studied, including content of galactosylated alginate (100%, 50%, 30%, 0) and membrane formation time (5, 10, 20 minutes). RESULTS AND CONCLUSION: For the synthesis of galactosylated alginate, Fourier transform infrared spectra indicated the disappearance of carboxylic groups and the formation of C-N bonds. Nuclear magnetic resonance spectroscopy suggested that not only the peak corresponding to lactobionic acid appeared in the product, but also some ethyl (dimethylaminopropyl) carbodiimide chains were coupled. According to elemental analysis, the calculated galactose grafting content was 20%, and the coupling ethyl (dimethylaminopropyl) carbodiimide C was 8%. Due to decrease of the negative charge of the alginate molecular chains after coupling, the electrostatic complex membrane formation was affected. The microcapsules possessing mechanical stability can be obtained when the content of galactosylated alginate sodium is lower than 50% in the mixture of galactosylated alginate sodium and alginate sodium. Figures and Tables | References | Related Articles | Metrics

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Pilose antler polypeptide composite membrane supports a suitable microenvironment for peripheral nerve regeneration  Wang Ke-li, Lu Lai-jin, Zhang Jing-ling, Li Xiang-jun, Jing Xia-bin 2013, 17 (25):  4652-4659.  doi: 10.3969/j.issn.2095-4344.2013.25.013 Abstract ( 361 )   PDF (1041KB) ( 608 )   Save BACKGROUND: Studies have confirmed that polylactic acid-polyglycolic acid membrane has good biocompatibility, stable mechanical strength, non-toxic side effects and controllable degradation rate. Pilose antler polypeptide contains a variety of active materials, basically promoting DNA synthesis and cell differentiation. OBJECTIVE: To investigate the repair effect of pilose antler polypeptide-polylactic acid-polyglycolic acid copolymer composite membrane on sciatic nerve injuries in rats. METHODS: Thirty-six male Wister rats were subject to expose the sciatic nerve after surgery and then randomly divided into sham operation group, control group and experimental group. Rats in the sham operation group received no treatment after removal of the sciatic nerve; those in the control group underwent direct end-to-end nerve anastomosis; while those in the experimental group were wrapped by pilose antler polypeptide-polylactic acid-polyglycolic acid copolymer composite membrane after the end-to-end nerve anastomosis. Four rats were collected from each group, respectively, at postoperative weeks 2, 4, 6 for histological examination, immunohistochemical examination and reverse transcription-PCR detection. RESULTS AND CONCLUSION: (1) Histological detection: 2, 4, 6 weeks after operation, the regeneration ratios and degree of maturity of neurites ranked as follows: the control group < the experimental group < the sham operation. (2) Immunohistochemical detection: 2, 4, 6 weeks after operation, the transforming growth factor β, insulin-like growth factors antigen dyeing and antigen expression of neurites and myelin sheath ranked as follows: the sham operation group < the control group < the experimental group. (3) Reverse transcription-PCR: 6 weeks after operation, the mRNA expression of transforming growth factor β and insulin-like growth factors was detected as follows: the sham operation group < the control group < the experimental group. These results suggest that pilose antler polypeptide-polylactic acid-polyglycolic acid copolymer composite membrane can provide the necessary microenvironment of nerve regeneration and nerve growth factor, and promote the peripheral nerve regeneration. Figures and Tables | References | Related Articles | Metrics

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Aldehyde seaweed polysaccharide composites serve as artificial liver carriers   Yu Mei-li, Du Zhi, Han Tao, Wang Ya-rong, Chen Jing, Guo Hong-yue, Li Nan, An Shuai-xing 2013, 17 (25):  4660-4667.  doi: 10.3969/j.issn.2095-4344.2013.25.014 Abstract ( 582 )   PDF (896KB) ( 545 )   Save BACKGROUND: During the three-dimensional culture in vitro, hepatocytes can grow well in the pores of the scaffold, but enzymatic digestion for decellularization severely affects cell survival rate and activity. OBJECTIVE: To prepare a macroporous scaffold, N-poly-isopropyl acrylamide-aldehyde seaweed polysaccharides, and to investigate the feasibility of this scaffold as a cell carrier for artificial liver bioreactor. METHODS: Sodium alginate as the porogen was used to synthesize the macroporous N-poly-isopropyl acrylamide that was then cross-linked with aldehyde seaweed polysaccharides to prepare the macroporous three-dimensional cytoskeleton. Scaffold aperture and porosity were measured. (1) Cytotoxicity test: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to detect absorbance values of mouse fibroblasts cultured in fresh cell culture medium, high-density polyethylene extract, high-density polyvinyl chloride extract and N-poly-isopropyl acrylamide-aldehyde seaweed polysaccharide extract. (2) Non-enzymatic acellular performance tests: The third generation of mouse fibroblasts cell line was inoculated into 6-well plates containing N-poly isopropylacrylamide-aldehyde seaweed polysaccharide scaffolds. In the experimental group, cells were recovered by cooling desorption, while in the control group, the cells were recovered using trypsin digestion method. RESULTS AND CONCLUSION: The aperture and porosity of the macroporous scaffold were (180.23±62.30) μm and (89.67±2.40)%, respectively. Cytotoxicity test showed that the macroporous scaffold of N-poly-isopropyl acrylamide-aldehyde seaweed polysaccharide had no cytotoxicity. The cell survival rate in the experimental group was increased 26.24% than that in the control group. These findings indicate that the three-dimensional macroporous cytoskeleton, N-poly-isopropyl acrylamide-aldehyde seaweed polysaccharide, has a macroporous structure suitable for cell growth, and thermo-responsive acellular performance overcomes cellular damage resulting from traditional enzymatic digestion and promotes the number of quality of cultured cells. Figures and Tables | References | Related Articles | Metrics

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Preparation and selection of a new sodium alginate-heparin composite coating with multi-aldehyde groups   Gao Wen-qing, Li Tong, Yu Mei-li, Hu Xiao-min, Duan Da-wei, Xu Jin 2013, 17 (25):  4668-4675.  doi: 10.3969/j.issn.2095-4344.2013.25.015 Abstract ( 366 )   PDF (938KB) ( 558 )   Save BACKGROUND: Preliminary experiments have demonstrated that composite coating of sodium alginate and heparin with multi-aldehyde groups has excellent biocompatibility and hemocompatibility. However, little is know about the optimal condition and pattern of new coating preparation. OBJECTIVE: To prepare a new composite coating of sodium alginate and heparin, and to optimize the coating preparation conditions. METHODS: The optimal coating conditions of sodium alginate (or heparin) were screened by orthogonal experiment, to obtain three coating patterns of sodium alginate/heparin composite. Composite coating was covalently bonded on the polyvinyl chloride surface which was preprocessed by amination/chemical modification. The screening methods of optimal composite coating pattern included coating quantification, protein adhesion test and surface contact angle. Anticoagulation properties of optimum composite coating model were assessed. RESULTS AND CONCLUSION: The optimum coating condition of oxidated sodium alginate in composite coating was 50% concentrated sulphuric acid, 0.05% polyethyleneimine, pH 3.5, reaction temperature 40℃ and 2 g/L oxidated sodium alginate. The optimum coating condition of heparin in composite coating was 70% concentrated sulphuric acid, 0.1% polyethyleneimine, pH 3.5, reaction temperature 30 ℃ and 0.1 g/L low molecular nitrous acid-converted heparin. The quantities of oxidated sodium alginate and heparin in optimum composite coating pattern were (4.07±1.35) and (2.13±0.24) μg/cm2. And the composite coating possesses fine anticoagulant property and biocompatibility. Figures and Tables | References | Related Articles | Metrics

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Silk/poly(lactic-co-glycolic acid) scaffold degradation fluid and proliferation of bone marrow mesenchymal stem cells   Zhang Wen-yuan, Yang Ya-dong, Li Ying, Zhang Ke-ji, Fang Guo-jian, Tang Liang, Li Yue-zhong, Wang Han, Lu Ming-yang 2013, 17 (25):  4676-4683.  doi: 10.3969/j.issn.2095-4344.2013.25.016 Abstract ( 286 )   PDF (729KB) ( 533 )   Save BACKGROUND: Previous studies showed that silk/poly(lactic/co-glycolic acid) copolymer scaffold has good cytocompatibility and no cytotoxicity. OBJECTIVE: To observe the effects of degradation fluid of silk/poly(lactic-co-glycolic acid) braided scaffold on the proliferation and growth of rabbit bone marrow-derived mesenchymal stem cells in vitro. METHODS: The silk/poly(lactic-co-glycolic acid) braided scaffold was degraded in complete culture medium for 14 weeks in vitro, and medium was replenished every week. The pH value of degradation fluid of the scaffold was determined every week. Rabbit bone marrow mesenchymal stem cells were cultured with degradation fluid and complete medium each 100 µL (experimental group), while negative control group was added with complete medium 200 µL, culturing for 4 days. The proliferation and growth of mesenchymal stem cells was detected with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. RESULTS AND CONCLUSION: (1) pH value changes of degradation fluid of silk/poly(lactic-co-glycolic acid) scaffold: pH value declined slowly with the first 3 weeks, from 7.00 to 6.89. However, the value went down quickly at 4 weeks, maintained a low level at 6-11 weeks, between 5.16 and 5.67. Then pH values increased at 12-14 weeks, rising to 6.95. (2) Morphology of mesenchymal stem cells: The proliferation and growth of mesenchymal stem cells in experimental group and negative control group were basically similar. Degradation fluid inhibited the cell growth at degradation 7-10 weeks, exhibiting relatively less counts and sparse arrangement of the cells, while degradation fluid in other weeks had no obviously inhibition on the cell growth. (3) Proliferation of mesenchymal stem cells: Degradation fluid of the scaffolds at 1-6 weeks and 11-14 weeks had no significant impact on cell proliferation, and the relative growth rates of the cells were all over 92.1%, with toxicity grade 0 or 1 level; degradation fluid at 7-10 weeks had an inhibition effect on cell proliferation, but relative growth rates were 82.5%-87.9%, with toxicity grade 1 level, as qualified. Experimental findings indicate that, the degradation fluid of silk/poly(lactic-co-glycolic acid) braided scaffold has a good cytocompatibility. Figures and Tables | References | Related Articles | Metrics

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Preparation and characterization of a new kind of firm/soft adjusted poly(D,L-lactic acid)-polyurethane  Xu Jian, Peng Kun, Gan Xiao-ling,Wang Yi-zheng, Duan Qiao-ling, Ruan Chang-shun, Sun Jiao-xia 2013, 17 (25):  4684-4691.  doi: 10.3969/j.issn.2095-4344.2013.25.017 Abstract ( 491 )   PDF (932KB) ( 649 )   Save BACKGROUND: Biodegradable polyurethane is a focus in the field of biomedical materials. Poly(D,L-lactic acid)-polyurethane has a broad prospect in the biomedical field. OBJECTIVE: To prepare a new poly(D,L-lactic acid)-polyurethane based on the molecular designing, using D,L-lactide, 1,6-hexamethylene diisocyanate, 1,4-butanediol and 1,4-butanediamine. METHODS: The hydroxy-terminated poly(D,L-lactic acid) was synthesized by melt polymerization, and then1,6-hexamethylene diisocyanate was added as a crosslinker to produce poly(D,L-lactic acid)-polyurethane. These products were characterized by Fourier transform infrared spectrometry, nuclear magnetic resonance spectrometer, thermogravimetry/differential thermal analyzer and Instron 1121 universal tester to explore the structures and performance. RESULTS AND CONCLUSION: The chemical structure of the products was consistent with the expected molecular structure. To adjust the proportion of reactants, we realized the control of the firm/soft transition degree (from 472% to 112% of the elongation at break) and firm/soft transition temperature (from 36.33 ℃ to 44.04 ℃ of the glass transition temperature). These findings indicate that the biodegradable poly(D,L-lactic acid)- polyurethane has thermosensitive effect, and its elongation at break and glass transition temperature can be controlled, which is the application foundation in the field of biomedical engineering. Figures and Tables | References | Related Articles | Metrics

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Cyanoacrylate-nano drug: A bone-targeted therapy  He Wei, Liu Ming 2013, 17 (25):  4692-4698.  doi: 10.3969/j.issn.2095-4344.2013.25.018 Abstract ( 653 )   PDF (739KB) ( 617 )   Save BACKGROUND: Modified medical adhesives with α-cyanoacrylate as the main component can produce a large adhesive strength in a moist environment, such as carrying different types of drugs, achieving a sustained release of drug and inducing the creeping substitution of new bone tissue. OBJECTIVE: To analyze the physical and chemical characteristics of cyanoacrylate-nano drug delivery system so as to clarify its clinical prospect in the future and problems to be solved. METHODS: A computer-based online search of PubMed, CNKI databases was performed for articles published from January 2004 to October 2012 using the key words of “cyanoacrylate; nanoparticle drug delivery system; targeted therapy” in English and Chinese, respectively. Articles related to cyanoacrylate and nano-drugs bone targeted therapy were included. RESULTS AND CONCLUSION: In view of cyanoacrylate and its derivatives can be bonded quickly in the bone marrow cavity under moist conditions, have larger strength and can be degraded, cyanoacrylate-nano drug is used for bone targeted therapy. The FDA has upgraded cyanoacrylate applicable level from Class Ⅲ to Class Ⅱ. Future issues could make full use of the advantages of nano-drug targeted therapy, to achieve high drug load and controlled drug release; carry out interdisciplinary research to improve bonding strength, biomechanical strength and elastic modulus of bone-prosthesis interface; develop composite biomaterials thereby to improve the deficiency of single materials in performance. Compound nano-drug targeted therapy will be a great potential way to the treatment of bone tumors, bone tuberculosis and osteomyelitis. Figures and Tables | References | Related Articles | Metrics

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A membrane controlled release drug delivery system promotes injured tissue repair   Li Wei, Dai Jiang-hua, Luo Jun, Dai Min, Gao Qian-kun 2013, 17 (25):  4699-4706.  doi: 10.3969/j.issn.2095-4344.2013.25.019 Abstract ( 333 )   PDF (712KB) ( 605 )   Save BACKGROUND: At present many studies have pay attention to the sustained-release and controlled-release effects, as well as biocompatibility, in membrane controlled release drug delivery system. There are also some studies addressing the mechanisms underlying injured tissue repair with these drug membranes, in which stem cells are the key factors. However, the association between stem cells and the sustained and controlled drug release membrane has not yet been paid enough attention. OBJECTIVE: To analyze the current research status and progress of membrane sustained-release system in the repair of tissue injuries. METHODS: Using the keywords of “sustained-release system, membrane, drug delivery, injuries and repairs of tissue, stem cell homing” in Chinese and English, a computer search of PubMed, CNKI, Elsevier databases was performed for articles published from January 1992 to March 2012. Articles related to clinical application and experiment research of sustained-release and controlled-release pharmaceutical polymer materials were included. RESULTS AND CONCLUSION: In the membrane sustained-release system, polymer materials have almost become the critical part of drugs and growth factors in the process of infiltration and penetration. Although drug delivery system and membrane preparation technology are constantly updated, it is not enough to achieve the desired application standards, such as do not have the initiative to attract direct migration and distribution of stem cells. In recent years, there is a new development trend for membrane sustained-release system, which not only can induce stem cells homing to injury sites, but also can promote the differentiation and distribution of stem cells, thereby promoting the renovation of tissue injury. Figures and Tables | References | Related Articles | Metrics

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Biological and mechanical compatibility of biomedical titanium alloy materials   Yu Zhen-tao, Han Jian-ye, Ma Xi-qun, Yu Sen, Zhang Ming-hua, Zhang Yu-sheng 2013, 17 (25):  4707-4714.  doi: 10.3969/j.issn.2095-4344.2013.25.020 Abstract ( 1157 )   PDF (887KB) ( 1789 )   Save BACKGROUND: Biomechanical compatibility is the key factor for the research and development of surgical implants and orthopedic devices. But the present research lacks systematic and common knowledge. OBJECTIVE: To preliminarily analyze the concept and intension of biomechanical compatibility of biomedical titanium alloys in order to direct the designing and applying of medical devices. METHODS: A computer-based search was performed for articles related to biomechanical compatibility in PubMed, Elsiver, SpringerLink, CNKI and VIP databases (1995-2012) to investigate the effects of alloy elements, microstructure and its phase transformation, and surface modification on the biomechanical compatibility of titanium alloys. RESULTS AND CONCLUSION: It is a comprehensive evaluation for biomechanical compatibility. To design biomedical titanium alloys, first, there should be no toxic alloy elements to ensure the safety in the reaction with the tissue, blood, immune system and whole body; second, it is also required that added elements should have the minimum adverse effects on the mechanical properties and other performance of titanium alloys. Common alloy elements in titanium alloys include α-phase stable element, β-phase stable element, and neutral element. It is important for better biomechanical compatibility of biomedical titanium alloys to control microstructure and phase transitions and even carry out surface modification. But we cannot simply pursue the low modulus and high strength of a titanium alloy that is close or matching the human bone tissue, by which, we adjust the pros and cons of the biomechanical compatibility. Figures and Tables | References | Related Articles | Metrics

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Acellular dermal matrix used for guiding bone regeneration in the dental implant area Zhou Jing, Deng Cai, Zhang Jin-feng 2013, 17 (25):  4715-4720.  doi: 10.3969/j.issn.2095-4344.2013.25.021 Abstract ( 479 )   PDF (894KB) ( 609 )   Save BACKGROUND: Acellular dermal matrix is a kind of prosthodontics membrane material which has been widely used due to the good biocompatibility. OBJECTIVE: To evaluate the effect of acellular dermal matrix in guiding bone regeneration in the dental implant area. METHODS: Immunohistochemical staining was performed, and the microscope was used to observe the microstructure and cell compatibility of acellular dermal matrix, in order to evaluate the feasibility of acellular dermal matrix in guiding bone regeneration. The dental implantation patients who received bone regeneration with acellular dermal matrix were followed-up to evaluate the osteogenesis effect and the effect on soft tissue defects. Then, the effects of Bio-Gide membrane and Bot medical collagen membrane on guiding bone regeneration were compared. RESULTS AND CONCLUSION: The microstructure of acellular dermal matrix showed there was basement membrane surface and tissue surface. The stylode-like structure and hair follicle could be observed on the basement membrane surface and the tissue surface was scaly structure, and acellular dermal matrix had no influence on the proliferation activity osteoblast-like cells and the alkaline phosphatase activity, but had good cell compatibility. The clinical researches showed that acellular dermal matrix used in dental implantation was effective for bone regeneration, and there was no significant difference in the effect on guiding bone regeneration when compared with Bio-Gide membrane and Bot medical collagen membrane. The acellular dermal matrix had good bone regeneration effect in repairing soft tissue deficiencies after bone augmentation. Figures and Tables | References | Related Articles | Metrics

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Application of braided retraction cord in dentistry  Zhang Yan-jun 2013, 17 (25):  4721-4726.  doi: 10.3969/j.issn.2095-4344.2013.25.022 Abstract ( 477 )   PDF (574KB) ( 578 )   Save BACKGROUND: Gingival is the important part in the preparation of standard dental body and accurate impression, which has great significance in the repairing of diseased teeth. OBJECTIVE: To evaluate the application effect of braided retraction cord in dentistry. METHODS: The patients who received braided retraction cord for repairing of dental defects were followed-up, and the effect of retraction cord on dentistry through assessing the satisfaction of dentistry and the related complications of gingival bleeding, gingivitis and periodontitis. The effect of retraction cord with different structural characteristics in dentistry was compared. RESULTS AND CONCLUSION: The braided retraction cord for the repairing of 367 anterior and 64 posterior dental defects could reduce the incidence of periodontal complications of gum discoloration, gingival bleeding, gingivitis and periodontitis. Domestic retraction cord as it contains alum has a good hemostatic function and can obtain satisfactory restoration effect. The import retraction cord has the same hemostatic function and can obtain satisfactory restoration effect due to its mesh weave structure. There is no significant difference of satisfaction rate during the dental repairing. Figures and Tables | References | Related Articles | Metrics

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Changes of pulmonary function after bone injury treated with polymethylme-thacrylic bone cement   Guan Ji-kui, Zhao Li, Jiang Yu, Li Ze-bao1 Chao Peng-cheng, Wei Min-jie, Wang Hui, Liu Jian-guo 2013, 17 (25):  4727-4732.  doi: 10.3969/j.issn.2095-4344.2013.25.023 Abstract ( 379 )   PDF (686KB) ( 436 )   Save BACKGROUND: At present, the polymethylme-thacrylic bone cement filling has been widely used in the treatment of fractures and bone injuries during arthroplasty. The pulmonary function changes caused by polymethylme-thacrylic bone cement filling, especially the elderly bone injury patients, should be prevented and treated actively. OBJECTIVE: To observe the pulmonary function changes after bone injury treated with polymethylme-thacrylic bone cement filling. METHODS: Twenty-four patients with fractures and arthroplasty bone injury were selected from the Department of Orthopedics, Daqing Oilfield General Hospital between May 2010 and June 2011. The patients were treated with polymethylme-thacrylic bone cement filling. Vital capacity, forced vital capacity and maximum voluntary ventilation changes were compared after treated for 1 day and 1 week. RESUTLS AND CONCLUSION: For the patients with fractures and arthroplasty bone injury after  treated with polymethylme-thacrylic bone cement filling for 1 day, the vital capacity was (2.45±0.56) L, forced vital capacity was (2.20± 0.39) L and maximum voluntary ventilation was (50.9±23.9) L, which were lower than those after treated for 1 week. Polymethylme-thacrylic bone cement filling can affect the pulmonary function of the patients to some extent, and this change may relate with microvascular embolization caused by bone cement application. So pulmonary embolism should be prevented and treated through strengthen monitoring, and durgs application before and after treatment. Figures and Tables | References | Related Articles | Metrics

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Bioabsorbable tension band for the treatment of ulnar styloid fracture  Zhou Qiang, Lu Hua, Wang Zhan-chao, Mao Yu-lun, Yu Si-ming 2013, 17 (25):  4733-4738.  doi: 10.3969/j.issn.2095-4344.2013.25.024 Abstract ( 505 )   PDF (671KB) ( 572 )   Save BACKGROUND: Selection of the appropriate internal fixation materials is an important factor in the success of fracture treatment. Bioabsorbable materials will become the hotspot fracture research. OBJECTIVE: To investigate the material characteristics of bioabsorbable tension band and the effect on the treatment of ulnar styloid fracture. METHODS: Thirty-six patients with ulnar styloid fracture that treated with bioabsorbable tension band and Kirschner from November 2009 to February 2012 were selected for cases analysis, including 21 male patients and 15 female patients; the age of the patients was 21-73 years, average 35.7 years. The bone fracture healing and wrist joint function was observe after treatment, and the material types, characteristics and fixation strength were in-depth studied. The pros and cons of bioabsorbable tension band and metal tension band were compared. RESUTLS AND CONCLUSION: All the 36 ulnar styloid fracture patients were treated with bioabsorbable tension band and followed-up for 2 months to 2.5 years, average 8.5 years. X-ray examination showed the fractures were healed. The wrist joint function was evaluated with GartIand-Werley, and the results showed 24 cases of excellent, 10 cases of good, one case of average and one case of poor, and the excellent and good rate was 94%. The results indicate that bioabsorbable tension band is favorable for the recovery of joint function, and can gradually transfer the strain during fracture healing and maintain the strength on the fracture site. The degradability of the material can help to avoid the pain of secondary surgery. From the results we can indicate that bioabsorbable tension band and Kirschner wire is the ideal method for the treatment of ulnar styloid fracture. Figures and Tables | References | Related Articles | Metrics

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Noninvasive penetration resin materials repair early stage deciduous caries   Mao Qing-hua, Ge Qing-hua, Ning Jia, Jiang Hai-ying 2013, 17 (25):  4739-4744.  doi: 10.3969/j.issn.2095-4344.2013.25.025 Abstract ( 640 )   PDF (603KB) ( 739 )   Save BACKGROUND: Due to the anatomical location of early deciduous caries, plaque is difficult to remove, and the effect of conventional remineralization therapy is poor. OBJECTIVE: To observe the clinical effect of noninvasive penetration resin for the treatment of early deciduous caries. METHODS: 120 teeth with early deciduous caries were collected and divided into penetration resin group and flowable resin group, 60 teeth in each group. The teeth were treated with penetration resin and flowable resin respectively. The tooth morphology of caries, enamel demineralization removing caused chalk stains and color stability, secondary caries and treatment success rate were evaluated at 1-year follow-up after treatment. RESULTS AND CONCLUSION: The efficacy at 1 year after filling treatment showed that tooth morphology of caries, enamel demineralization removing caused chalk stains and color stability, and secondary caries in the penetration resin group were better than those in the flowable resin group. The treatment success rate in the penetration resin group (96.7%) was significantly higher than that in the flowable resin group (76.7%), and the difference was significant (P < 0.05). Noninvasive penetration resin material is the simple and efficient method to prevent the development caries. Figures and Tables | References | Related Articles | Metrics

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Biocompatibility of intraocular lens materials Wang Yang, Han Hong-guang 2013, 17 (25):  4745-4750.  doi: 10.3969/j.issn.2095-4344.2013.25.026 Abstract ( 531 )   PDF (643KB) ( 1028 )   Save BACKGROUND: The visual recovery and complications of the cataract patients are various after different intraocular lens materials implantation, so the selection of appropriate intraocular lens materials is the key of the research. OBJECTIVE: To investigate the properties and biocompatibility of intraocular lens materials. METHODS: The materials were classified according to the hardness and location of the intraocular lens after implantation in order to analyze the pros and cons of the intraocular lens thus guiding the patients to select the appropriate intraocular lens for implantation. The properties and biocompatibility of the commonly used intraocular lens materials were evaluated. RESUTLS AND CONCLUSION: Polymethylmethacrylate intraocular lens is the first choice of rigid material, but it cannot tolerate autoclaving. Acrylic intraocular lens is the soft and foldable intraocular lens that has the similar optical and biological properties with polymethylmethacrylate intraocular lens, and it can improve the visual acuity after implantation with less complications. Posterior capsular opacification is the most important indicator for biocompatibility evaluation which is related with the material and design of intraocular lens. The stability of intraocular lens in the capsular bag is also the indicator to evaluate the biocompatibility. The material properties, biocompatibility, and visual function should be taking into consideration in the design and selection of intraocular lens materials. Guarantee the efficacy after intraocular lens implantation and reduce the incidence of complications, so that to get vision rehabilitation for the cataract patients. Figures and Tables | References | Related Articles | Metrics