Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (33): 6194-6197.doi: 10.3969/j.issn.1673-8225.2010.33.028

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Directional differentiation of tissue engineered chondrocytes

Zhou Jun-jie1, Yu Guang-rong2, Cao Cheng-fu1, Chen Xian-qi1, Pang Jin-hui1, Shi Ji-xiang1   

  1. 1 Department of Orthopaedics, Putuo Affiliated Hospital of Shanghai University of Chinese Medicine, Shanghai  200062, China; 2 Department of Orthopaedics, Tongji Hospital of Tongji University, Shanghai  200065, China
  • Online:2010-08-13 Published:2010-08-13
  • Contact: Yu Guang-rong, Chief physician, Professor, Doctoral supervisor, Department of Orthopaedics, Tongji Hospital of Tongji University, Shanghai 200065, China yuguangrong2002@yahoo.com.cn
  • About author:Zhou Jun-jie★, Master, Associate chief physician, Department of Orthopaedics, Putuo Affiliated Hospital of Shanghai University of Chinese Medicine, Shanghai 200062, China boysroger@126.com
  • Supported by:

     the Shanghai Key Discipline Item, No: T0303*

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Abstract:

BACKGROUND: Articular cartilage cannot repair completely after injury, which is liable to degenerative change under physiological stress, eventually develops into osteoarthritis. Therefore, repairing damaged articular cartilage using tissue engineered chondrocytes provide a new approach for articular cartilage disease treatment.
OBJECTIVE: To understand the biological characteristics and construction of tissue engineered chondrocytes, and to define the progress of directed differentiation of tissue engineered chondrocytes.
METHODS: Chinese Biomedical Literature Database and Medline database were retrieved for papers concerning tissue engineered chondrocytes published between 1994 and 2009. The progress of inductive seed cells and regulation pathway were analyzed.
RESULTS AND CONCLUSION: Totally 27 literatures were selected. Growth factor in extracellular matrix plays an important role in the growth and differentiation of cartilage via controlling cell signaling pathways. Simultaneously, surrounding environment of chondrocytes also affects cartilage differentiation. However, the relationships among signaling pathways are poorly understood. The scaffold materials for tissue engineered chondrocytes construction need to be improved.

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