Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (33): 6198-6201.doi: 10.3969/j.issn.1673-8225.2010.33.029

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Growth factor participates in bone reconstruction under stress

Wang Li, Zhao Wen-zhi, Li Bin, Su Jin   

  1. Department of Orthopedics, Second Affiliated Hospital of Dalian Medical University, Dalian  116023, Liaoning Province, China
  • Online:2010-08-13 Published:2010-08-13
  • Contact: Zhao Wen-zhi, Doctor, Professor, Master’s supervisor, Department of Orthopedics, Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China drzwz@163.com
  • About author:Wang Li★, Studying for master’s degree, Department of Orthopedics, Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China juhongshan@yahoo.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 30970708*

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Abstract:

BACKGROUND: Skeleton can remodel its shapes and rebuild sclerotin in the process of growth or mature. Various growth factors involve in this procedure under stress.
OBJECTIVE: To explore the produce and expression of growth factor in bone reconstruction under stress.
METHODS: Databases of PubMed (1970-01/2009-12), CNKI and CBM (1990-01/2009-12) were retrieved by computer to search documents with regard to growth factor participation in bone reconstruction under stress, and the effects of growth factor on bone reconstruction were analyzed.
RESULTS AND CONCLUSION: Totally 28 papers were included. The environment of the stress can prompted the proliferation of cells, induce the rearrangement of cytoskeleton and the change of cellular shape, accelerate the mineralization of cell matrix, boost the release of cytokine and bone hormones (bone morphogenetic protein, prostaglandin E2, as well as insulin-like growth factor 1), then to control the metabolism of bone, to stimulate the growth and the remodeling of bone. However, the transfer mechanism of stress on cells is unclearly, and the interactions between stress and remodeling adaptation of bone remains poorly understood.

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