中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (36): 6809-6812.doi: 10.3969/j.issn.1673-8225.2010.36.036

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

间充质干细胞分化的调控机制及其影响因素

华艳龙，李彩萍   

  1. 内蒙古医学院第一附属医院内分泌科，内蒙古自治区呼和浩特市  010050
  • 出版日期:2010-09-03 发布日期:2010-09-03
  • 通讯作者: 李彩萍，教授，内蒙古医学院第一附属医院内分泌科，内蒙古自治区呼和浩特市 010050 licp_nfm@163.com
  • 作者简介:华艳龙★，男，1986年生，内蒙古自治区巴彦淖尔市人，汉族，内蒙古医学院在读硕士，主要从事自体干细胞治疗糖尿病下肢血管病变的研究。 nmgyxhyl@163.com
  • 基金资助:

    内蒙古医学院附属医院重大科研项目(NMFYZD2008003)。

Regulatory mechanisms and influential factors of mesenchymal stem cell differentiation

Hua Yan-long, Li Cai-ping   

  1. Department of Endocrinology, First Affiliated Hospital, Inner Mongolia Medical College, Hohhot  010050, Inner Mongolia Autonomous Region, China
  • Online:2010-09-03 Published:2010-09-03
  • Contact: Li Cai-ping, Professor, Department of Endocrinology, First Affiliated Hospital, Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region, China licp_nfm@163.com
  • About author:Hua Yan-long★, Studying for master’s degree, Department of Endocrinology, First Affiliated Hospital, Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region, China nmgyxhyl@163.com
  • Supported by:

    the Major Scientific Research Program of Hospital Affiliated to Inner Mongolia Medical College, No. NMFYZD2008003*

PDF

541

被引次数

18

摘要：

背景：随着人们对间充质干细胞认识的深入，该细胞目前广泛应用于组织工程研究，例如缺血性脑血管病，肢体缺血等疾病的治疗等。
目的：综述影响骨髓间充质干细胞分化能力因素的研究进展。
方法：应用计算机检索2003-08/2009-08 PubMed数据库相关文章，检索词为“mesenchymal stem cell differentiation，Wnt，β-catenin，bone morphogenetic protein，vascular endothelial growth factor”，共收集到213篇相关文献。纳入与间充质干细胞分化调控机制及其影响因素相关文章，排除重复研究及Meta分析，最后纳入15篇文献进行总结。
结果与结论：随着生物工程等学科的发展，人们对间充质干细胞分化的调控及其影响因素有了进一步的认识。在间充质干细胞的生存微环境内发现了许多因子如骨形态发生蛋白、血管内皮生长因子等，它们在调节细胞的分化上发挥了重要作用。相应对外界因素如何产生效应的认识也越来越多，如对细胞膜电位作用的认识。间充质干细胞的某些自身因素影响到了其分化能力，细胞的衰老就是其中的一种。

关键词: 间充质干细胞, 信号转导, 细胞衰老, 调控, 综述文献

Abstract:

BACKGROUND: Along with the thorough understanding of mesenchyma stem cells (MSCs) that present widespread application in tissue engineering research. For example, the treatments of anemic cerebrovascular disease, body ischemia and so on.
OBJECTIVE: To understand the research progress of the ability of bone marrow mesenchymal stem cell (BMSC) differentiation.
METHODS: A computerized search through the PubMed database was undertaken from August 2003 to August 2009. The key words were “mesenchymal stem cell differentiation, Wnt, ß-catenin, bone morphogenetic protein, vascular endothelial growth factor”. Totally, 213 literatures were collected. Articles concerning regulatory mechanisms and influential factors of MSC differentiation were included;Repetitive studies and Meta analysis were excluded.Finally,15 articles were used for the review.
RESULTS AND CONCLUSION: With the development of bioengineering disciplines, people know more about the regulation of BMSCs differentiation and influential factors. Many factors found in the survival of MSC microenvironment such as bone morphogenetic protein and vascular endothelial growth factors, which play an important role in regulating cell differentiation. The external factors also play an important role, such as the membrane potential. MSC senescence may affect the ability of cell differentiation.

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