中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (27): 5112-5114.doi: 10.3969/j.issn.1673-8225.2011.27.039

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

神经干细胞移植在脑损伤治疗中的应用

陈  岚，李  玫   

  1. 贵州省人民医院神经内科，贵州省贵阳市  550002
  • 收稿日期:2011-01-05 修回日期:2011-04-09 出版日期:2011-07-02 发布日期:2011-07-02
  • 通讯作者: 李玫，医师，贵州省人民医院神经内科，贵州省贵阳市550002
  • 作者简介:陈岚，女，1969年生，浙江省宁波市人，汉族，1991年遵义医学院临床医学系毕业，主要从事脑血管疾病的研究。

Application of neural stem cell transplantation to brain injury therapy

Chen Lan, Li Mei   

  1. Department of Neurology, Guizhou Provincial People’s Hospital, Guiyang  550002, Guizhou Province, China
  • Received:2011-01-05 Revised:2011-04-09 Online:2011-07-02 Published:2011-07-02
  • Contact: Li Mei, Physician, Department of Neurology, Guizhou Provincial People’s Hospital, Guiyang 550002, Guizhou Province, China
  • About author:Chen Lan, Physician, Department of Neurology, Guizhou Provincial People’s Hospital, Guiyang 550002, Guizhou Province, China

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363

被引次数

2

摘要：

背景：成年鼠脑纹状体中已分离出具有分化成神经元及各种胶质细胞潜能的神经干细胞后，医学工作者试图从中寻找新思路用于脑损伤的治疗。
目的：总结神经干细胞移植对治疗脑损伤中的作用及其前景。
方法：电子检索EMbase(1980-01/2011-04)，MEDLINE(1966-01/2011-04)，中国生物医学文献数据库(CBM，1978/2011-04)和中国期刊全文数据库(CNKI)，筛查相关文章的参考文献。中文检索词“神经干细胞，脑损伤，脑卒中，脑梗死”，英文检索词“neural stem cells, brain injury, stroke, cerebral infarction”，最终纳入符合标准的文献12篇。
结果与结论：动物研究结果显示神经干细胞移植可以改善神经功能并且明显降低脑组织炎症反应，沉默NgR基因、GDNF基因修饰和联合移植BDNF可更大程度上恢复神经功能。临床试验发现神经干细胞移植能在一定程度上改善脑卒中患者的后遗症。提示神经干细胞移植在动物实验中获取明显效果，可进一步应用于临床并研究其疗效。

关键词: 神经干细胞, 移植, 脑损伤, 应用

Abstract:

BACKGROUND: Neural stem cells (NSCs), which have the potential of differentiating into neurons and various glial cells, have been isolated from corpus striatum of adult rat brain.
OBJECTIVE: To summarize the effect and perspective of NSC transplantation in treatment of brain injury.
METHODS: EMbase (1980-01/2011-04), Medline (1966-01/2011-04), Chinese BioMedical Literature Database (1978/2011-04) and China National Knowledge Infrastructure were retrieved for relevant articles. The key words were “neural stem cells, brain injury, stroke, cerebral infarction”, and finally 12 articles were included.
RESULTS AND CONCLUSION: Results of animal study demonstrated that NSC transplantation could improve neural function and significantly decrease inflammatory reaction in the brain tissues. Silencing NgR gene, GDNF gene modification and combined transplantation of brain-derived neurotrophic factor could recover neural function to a greater degree. Clinical trials found that NSC transplantation could improve sequela after stroke to some degrees. These suggest that NSC transplantation obtained obvious outcomes, and could be futher utilized in clinic and for studying its clinical outcomes.

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