关键词: 生物可降解, 药物洗脱支架, 雷帕霉素, 紫杉醇, 经皮冠状动脉, 急性冠脉综合征

Abstract:

OBJECTIVE: To describe the biocompatibility of biodegradable materials, influence of biodegradable materials on the arterial intima and smooth muscle, and clinical application progress of biodegradable stents.
METHODS: Using “biodegradable; drug-eluting stent; rapamycin; paclitaxel; percutaneous coronary; acute coronary syndrome” in Chinese as the search word, Chinese Academic Journal Full-text Database (CNKI: 2002/2010) was searched on computer. Repeated research and old literature were excluded, 19 articles were screened out.
RESULTS: At present, more biodegradable scaffold for the poly-L-lactic acid, polyglycolic acid/polylactic acid copolymer, and good biocompatibility. Biodegradable materials on human umbilical arterial smooth muscle cell growth was not affected, but with paclitaxel or rapamycin biodegradable materials inhibit the growth of arterial smooth muscle cells, and also animals intimal proliferation. Biodegradable stent in the near, medium-term clinical study prove to be safe and effective.
CONCLUSION: Biodegradable scaffolds have good biocompatibility, the thrombosis, foreign body reaction and neointimal hyperplasia are reduced after implantation, while endothelialization is more complete. The local release of drugs could inhibit the early thrombosis and late neointimal hyperplasia, this conclusion needs further confirmation by large-scale, multi-center randomized controlled trials.