中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (26): 4864-4867.doi: 10.3969/j.issn.1673-8225.2011.26.029

• 骨与关节综述 bone and joint review • 上一篇    下一篇

骨形态发生蛋白7在骨科的应用

沈  奕，李晓淼，王伟力   

  1. 上海交通大学附属仁济医院骨科，上海市  201615
  • 收稿日期:2011-01-10 修回日期:2011-04-25 出版日期:2011-06-25 发布日期:2011-06-25
  • 通讯作者: 王伟力，硕士，主任医师，教授，主要从事关节外科。上海交通大学附属仁济医院骨科，上海市 201615 drwangwl@126.com
  • 作者简介:沈奕★，男，1974年生，硕士，主治医师，主要研究髋关节置换后假体松动的相关机制。 mrshenyi@126.com
  • 基金资助:

    上海市科委非政府间国际科技合作项目(09410706100)。

Application of bone morphogenetic protein 7 in the orthopedics

Shen Yi, Li Xiao-miao, Wang Wei-li   

  1. Department of Orthopedics, Renji Hospital of Shanghai Jiao Tong University, Shanghai  201615, China
  • Received:2011-01-10 Revised:2011-04-25 Online:2011-06-25 Published:2011-06-25
  • Contact: Wang Wei-li, Master, Chief physician, Professor, Department of Orthopedics, Renji Hospital of Shanghai Jiao Tong University, Shanghai 201615, China drwangwl@126.com
  • About author:Shen Yi★, Master, Attending physician, Department of Orthopedics, Renji Hospital of Shanghai Jiao Tong University, Shanghai 201615, China mrshenyi@126.com
  • Supported by:

    the Non-governmental International Scientific and Technological Cooperation Project of Shanghai Science and Technology Committee, No.09410706100*

PDF

849

被引次数

23

摘要：

背景：骨形态发生蛋白家族因具有独特的异位骨诱导活性而被发现并被命名为骨形态发生蛋白，与胚胎组织的发育、功能维持及组织的修复均密切相关，是诱导骨发生的主要活性因子。骨形态发生蛋白7是骨形态发生蛋白家族中的一员，主要在骨、肾组织中表达，与胚胎组织的发育、功能维持及组织的修复均密切相关。
目的：全面了解骨形态发生蛋白7在骨发育和骨折愈合过程中的表达及作用。
方法：电子检索和计算机Medline数据库1990/2010收录的骨形态发生蛋白相关综述和论文报告，并分析生物学作用及调控途径的研究进展。
结果与结论：随着研究的深入，骨形态发生蛋白7可望在骨折愈合、退行性骨关节炎、相关骨病的防治中发挥重要的作用。骨形态发生蛋白7的生物学活性使其对骨折、骨缺损、延迟愈合，骨不连、骨质疏松等多种骨科疾病的治疗具有巨大的临床应用价值。已有证据表明骨形态发生蛋白局部应用或骨形态发生蛋白涂层有利于假体-骨界面的骨整合，包括假体周围骨缺损的治疗。

关键词: 骨形态发生蛋白, 骨形态发生蛋白7, 应用, 进展, 骨科

Abstract:

BACKGROUND: Bone morphogenetic protein (BMP) family have the unique ectopic osteoinduction activity. They are related with development of embryonic tissue, functions maintenance and organizational rebuilding. BMPs are important to osteoinduction activity. BMP7, one of BMPs, mainly in bone and kidney, is essential for development of embryonic tissue and organizational rebuilding.
OBJECTIVE: To understand the expression and role of BMP7 in bone development and fracture healing.
METHODS: BMPs relevant articles from Chinese biomedical literature database and Medline database 1990/2010 were retrieved. Then, the development of biology role and regulation path was studied.
RESULTS AND CONCLUSION: With deeply research, BMP7 may play an important role in fracture healing, recessive osteoarthritis, relative osteoarthritis diseases. There are some evidences to indicate that BMPs are profit for prosthesis-bone interfacial osseointegration.

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