中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (29): 5463-5466.doi: 10.3969/j.issn.1673-8225.2010.29.036

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

封堵器材料特征及与宿主的生物相容性

吴顺芬，陈  刚   

  1. 黔西南州人民医院儿科，贵州省兴义市  562400
  • 出版日期:2010-07-16 发布日期:2010-07-16
  • 作者简介:吴顺芬，女，1964年生，贵州省兴义市人，汉族，1986年遵义医学院毕业，副主任医师，主要从事小儿心血管疾病的治疗研究工作。 wushunfen@qq.com

Occluder material characteristics and biocompatibility with the host

Wu Shun-fen, Chen Gang   

  1. Department of Cardiology, People’s Hospital of Qianxinan Prefecture, Xingyi   562400, Guizhou Province, China
  • Online:2010-07-16 Published:2010-07-16
  • About author:Wu Shun-fen, Associate chief physician, Department of Cardiology, People’s Hospital of Qianxinan Prefecture, Xingyi 562400, Guizhou Province, China wushunfen@qq.com

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425

被引次数

6

摘要：

目的：评价不同种封堵器材料的性能以及置入体内与宿主的生物相容性，为其在临床上的应用提供参考依据。
方法：以“封堵器，封堵器材料，组织相容性，血液相容性，先天性心脏病”为中文关键词；以“blocking material，blocking material material，histocompatibility，blood compatibility，congenital heart disease” 为英文关键词，采用计算机检索2006-01/2010-03相关文章。纳入与有关生物材料与宿主相容性的文章；排除重复研究或Meta分析类文章。以30篇文献为重点进行探讨封堵器材料的种类、性能及应用前景。
结果：心脏封堵器的类型较多，而已国产Ampeatzer封堵器应用广泛，材料多为镍钛合金类，其宿主生物相容性较好，封堵效果也较好，因费用较低，临床广泛应用。
结论：金属材料制备的封堵器虽应用广泛，但不可避免存在着腐蚀现象，从而相容不良，可能会引发附近组织发炎，产生病变，造成溶血或凝血现象等。理想的封堵器材料无论材料本身还是其降解产物都不能产生炎症和毒性反应，所以良好生物相容性的封堵器需进一步开发研制。

关键词: 封堵器, 封堵器材料, 组织相容性, 血液相容性, 先天性心脏病

Abstract:

OBJECTIVE: To evaluate the properties of different occluder materials and their biocompatibility with the host, to provide reference for its clinical applications.
METHODS: Using “occluder, blocking materials, histocompatibility, blood compatibility, congenital heart disease” in Chinese and “blocking material, occluder, histocompatibility, blood compatibility, congenital heart disease” in English as the key words, a computer search was performed for relevant articles between January 2006 and March 2010. Articles related to the biocompatibility of biomaterials with the host were included; repeated study or Meta analysis articles were excluded. Totally 30 articles mainly focuses on the type, properties and application prospect of occluder materials.
RESULTS: There are many types of cardiac occluder, domestic Ampeatzer occluder has been widely used, the materials are mainly the nickel-titanium alloy, with good biocompatibility, good blocking effect and low cost, thus widely applying in clinics.
CONCLUSION: Although metal occluder has been widely used, corrosion is inevitable, thus leading to poor compatibility and surrounding tissue inflammation, resulting in disease and hemolysis or clotting phenomena. Ideal occluder material, no matter the material itself or its degradation products, can produce no inflammation and toxicity, so the occluder with good biocompatibility need to be further developed.

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