中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (29): 5351-5354.doi: 10.3969/j.issn.1673-8225.2010.29.008

• 材料生物相容性 material biocompatibility • 上一篇    下一篇

超声辅助微弧氧化钛合金表面制备含镧涂层的生物相容性评价

刘继光1，包殿瑞1，毕庆伟2，邬志锋1，李慕勤3   

  1. 1佳木斯大学附属第二医院口腔医院，黑龙江佳木斯市 154002；2黑龙江省口腔病防治院，黑龙江哈尔滨市 150001；3黑龙江省高校生物医学材料重点实验室，黑龙江省佳木斯市 154007
  • 出版日期:2010-07-16 发布日期:2010-07-16
  • 通讯作者: 李慕勤，博士，教授，黑龙江省高校生物医学材料重点实验室，黑龙江省佳木斯市 154007 jmsdxlimuqin@163.com
  • 作者简介:刘继光☆，男，1961年生，黑龙江省绥化市人，汉族，2000年毕业于日本大阪大学博士学位，教授，主要从事口腔颌面外科学研究。 liujg5550@163.com

Ultrasound-assisted micro-arc oxidation to prepare biocoatings containing lanthanum on the surface of titanium alloy: Biocompatibility evaluation

Liu Ji-guang1, Bao Dian-rui1, Bi Qing-wei2, Wu Zhi-feng1, Li Mu-qin3   

  1. 1 The Affiliated Second Hospital and Dental Hospital of Jiamusi University, Jiamusi   154002, Heilongjiang Province, China; 2 Heilongjiang Provincial Oral Disease Prevention Hospital, Harbin   150001, Heilongjiang Province, China; 3 Biomedical Materials Key Laboratory of Universities of Heilongjiang Province, Jiamusi   154007, Heilongjiang Province, China
  • Online:2010-07-16 Published:2010-07-16
  • Contact: Li Mu-qin, Doctor Professor, Biomedical Materials Key Laboratory of Universities of Heilongjiang Province, Jiamusi 154007, Heilongjiang Province, China jmsdxlimuqin@163.com
  • About author:Liu Ji-guang☆, Doctor, Professor, The Affiliated Second Hospital and Dental Hospital of Jiamusi University, Jiamusi 154002, Heilongjiang Province, China liujg5550@163.com

PDF

586

被引次数

7

摘要：

背景：稀土元素具有一定的生物效应，也有广谱抗菌、抗炎和抗病毒的能力，能提高涂层结合强度作用。
目的：在种植体涂层中引入稀土镧，对引入稀土元素镧的钛基超声辅助微弧氧化涂层的生物相容性进行评价。
方法：利用超声辅助微弧氧化在β型钛合金表面制备含镧生物涂层，并植入家兔股骨内。以钛合金基体和未加镧生物涂层作对照。采用光镜观察新骨形成，通过扫描电镜观察种植体与骨的结合情况和拔出种植体后其表面骨残留，并对骨接触率进行数据统计。
结果与结论：实验组种植体周围新骨形成良好，未见到纤维形成和破骨细胞；扫描电镜观察及骨接触率以实验组最好，钛合金组最差。结果说明超声辅助微弧氧化制备的含镧生物涂层具有与新骨良好结合的能力，显示出较好的生物相容性。

关键词: 种植体, 镧离子, 钛合金, 超声波, 微弧氧化

Abstract:

BACKGROUND: Rare earth elements have some biological effects, and broad-spectrum anti-bacterial, anti-inflammatory and anti-virus capabilities, they can increase the bonding strength.
OBJECTIVE: To introduce rare earth lanthanum into the implant coating, and to evaluate the biocompatibility of ultrasound-assisted micro-arc oxidation preparing the lanthanum biocoating.
METHODS: Using ultrasound-assisted micro-arc oxidation, the biocoating containing lanthanum was prepared on the surface of the near β-type titanium alloy, and implanted in rabbit femur. The titanium alloy matrix and the micro-arc oxidation biocoating without lanthanum served as the control group. Optical microscope was used to observe the formation of new bone; Scanning electron microscopy was applied to observe the combination interface of implant and bone, and the bone residue after pulling the implant; the bone contact rate was statistically analyzed.
RESULTS AND CONCLUSION: In the experimental group, the new bone formed surrounding the implant without any fibers and osteoclasts; Scanning electron microscopy and bone contact rate are the best in the experimental group and the worst in the titanium alloy group. This shows that ultrasound-assisted micro-arc oxidation preparing the lanthanum biocoating can achieve high osseointegration and good biocompatibility．

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