中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (28): 5293-5296.doi: 10.3969/j.issn.1673-8225.2010.28.039

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

脊髓慢性损伤模型的构建

钱  军1，孙正义2，马维虎3   

  1. 1张掖市人民医院骨科，甘肃省张掖市 734000；2兰州大学第二医院骨科，甘肃省兰州市 730000；3宁波市第六医院脊柱外科，浙江省宁波市  315040
  • 出版日期:2010-07-09 发布日期:2010-07-09
  • 作者简介:钱 军★，男，1974年生，甘肃省张掖市人，汉族，2006年兰州大学毕业，硕士，副主任医师，主要从事脊髓损伤方面的研究。 qianjun0936@163.com
  • 基金资助:

    甘肃省中青年科技研究基金项目(0806RJYG018)。

Construction of chronic spinal cord injury models

Qian Jun1, Sun Zheng-yi2, Ma Wei-hu3   

  1. 1 Department of Orthopedics, Zhangye People’s Hospital, Zhangye  734000, Gansu Province, China; 2 Department of Orthopedics, Second Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China; 3 Department of Spine Surgery, Ningbo Sixth Hospital, Ningbo  315040, Zhejiang Province, China
  • Online:2010-07-09 Published:2010-07-09
  • About author:Qian Jun★, Master, Associate chief physician, Zhangye People’s Hospital, Zhangye 734000, Gansu Province, China qianjun0936@163.com
  • Supported by:

    the Young Science and Technology Research Fund of Gansu Province, No. 0806RJYG018*

PDF

471

被引次数

5

摘要：

背景：由于缺乏简单、理想的动物实验模型，脊髓病理改变及病理生理机制目前仍不明确。
目的：通过对脊髓慢性损伤动物模型综合叙述，为脊髓慢性损伤的动物实验研究提供参考，并进一步探讨脊髓慢性损伤摸型的建立与应用。
方法：以spinal cord injury，animal model，Models, Animal为检索词，应用计算机检索Medline等数据库相关文章，排除样本量太少及重复发表的文章，保留34篇文献做进一步分析。
结果与结论：脊髓损伤动物模型对于探求脊髓疾病的病因和病理机制，特别是对脊髓再生的神经生物学研究，评价脊髓损伤后有效的干预治疗措施有十分重要的作用。目前脊髓损伤动物模型虽然种类繁多，但各存优缺点，并且存在多种变异因素，如动物间个体差异、手术操作熟练程度及损伤装置的精密程度等，以致现有模型还无法准确控制脊髓损伤的范围和程度。故建立具有较强稳定性，能够反映特定病理变化的脊髓损伤动物模型一直是研究者追求的目标。

关键词: 脊髓损伤, 慢性, 骨组织工程, 动物模型, 病理变化, 大鼠

Abstract:

BACKGROUND: The pathology and pathophysiology of spinal cord remain poorly understood due to lack of simple and ideal animal models.
OBJECTIVE: To provide reference for the further establishment and application of chronic spinal cord injury models by comprehensive reviewing the chronic spinal cord injury models. 
METHODS: Articles published in Medline database were retrieved by computer using key words of “spinal cord injury, animal model, models, animal”. Documents with few samples or duplicated articles were excluded. Totally 34 literatures were remained for further analysis. 
RESULTS AND CONCLUSION: Animal models of spinal cord injury play an important role for exploring the etiology and pathogenesis of the spinal cord disease, especially in the neurobiology of spinal cord regeneration and evaluation of effective interventions after spinal cord injury treatments. Although the current animal models of spinal cord injury in a large variety of advantages and disadvantages of each deposit, there are many variation factors, such as individual differences among animals, the operation proficiency and the extent of damage precision device, which results in the existing models, can not accurately control the spinal cord injury in the scope and extent. Therefore, establishment of animal models of spinal cord injury with strong stability, and can reflect a specific pathological change has been a goal pursued by researchers.

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