中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (21): 3915-3918.doi: 10.3969/j.issn.1673-8225.2010.21.027

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

不同生物材料预防肌腱损伤后粘连的评价

周秀军   

  1. 扬州大学体育学院，江苏省扬州市   225009
  • 出版日期:2010-05-21 发布日期:2010-05-21
  • 作者简介:周秀军★，男，1971年生，江苏省泰州市人，汉族，硕士，讲师，主要从事体育保健学研究。 zxj@yzu.edu.cn

Evaluation on different biological materials to prevent adhesions after tendon injury

Zhou Xiu-jun   

  1. College of Physical Education, Yangzhou University, Yangzhou   225009, Jiangsu Province, China
  • Online:2010-05-21 Published:2010-05-21
  • About author: Zhou Xiu-jun★, Master, Lecturer, College of Physical Education, Yangzhou University, Yangzhou 225009, Jiangsu Province, China zxj@yzu.edu.cn

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530

被引次数

19

摘要：

目的：评价不同生物材料预防运动损伤修复后肌腱和腱鞘之间粘连的效果，寻找适合生物材料。
方法：以 “生物材料，肌腱损伤，术后粘连，临床应用”为中文关键词，“biological materials，tendon injury，conglutination”为英文关键词，采用计算机检索1990-01/2009-12相关文章。纳入与生物材料与组织工程骨缺损修复相关的文章；排除重复研究或Meta分析类文章。
结果：肌腱损伤后常见的并发症是肌腱粘连，骨折或关节损伤后常见的并发症也是肌腱粘连或关节粘连，其防治一直是医学界普遍关注的问题。目前国内外学者应用较多的是高分子化合物及药物薄膜屏障在防止肌腱粘连中的应用。几丁糖、透明质酸钠和聚-DL-乳酸药物薄膜是目前临床应用较多、并且较为成熟的技术，治疗效果也比较理想。5-氟尿嘧啶和生物蛋白胶在临床上也有应用，效果显著。金箔、胶原酶和甘油合剂等其他药物或材料，目前在临床上尚未见应用，仅限于动物实验阶段，在动物实验中，对预防肌腱粘连具有明显效果。
结论：科学合理的综合运用多种药物或高科技生物材料预防肌腱损伤后粘连将是未来的发展方向。

关键词:  , 药物, 材料, 肌腱损伤, 术后粘连, 临床应用, 生物材料

Abstract:

OBJECTIVE: To evaluate the effects of different biological materials to prevent the adhesion between tendon and tendon sheath following sports injury repair and to search for a suitable biological material.
METHODS: Using “biological materials, tendon injury, postoperative adhesions, clinical application” in Chinese and “biological materials, tendon injury, conglutination” in English as the key words, a computer search was performed for articles published between January 1990 and December 2009. Articles related to the biological materials and tissue engineering femoral defects were included; repeated study or Meta analysis articles were excluded.
RESULTS: Following tendon injury, the common complications are tendon adhesion, while tendon adhesion or joint adhesion is common after fracture or joint injury, its prevention and treatment has been a general concern in the medical field. Currently applied approach by domestic and foreign scholars is polymers and drug barrier in the prevention of tendon adhesion. Chitosan, hyaluronic acid and poly-DL-lactic acid film are mostly used and mature technology in the clinical application, achieving satisfactory treatment effect. 5-fluorouracil and fibrin glue are also seen in the clinical treatment, with remarkable effects. Other drugs or materials such as gold foil, collagenase and glycerol mixture, are not seen in the current clinical application and only limited to animal models, they showed obvious outcomes for the prevention of tendon adhesion in animal experiments.
CONCLUSION: The scientific and rational combination of various drugs or high-tech biological materials to prevent adhesions after tendon injury will be the future direction of medical development.

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