中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (26): 4857-4859.doi: 10.3969/j.issn.1673-8225.2011.26.027

• 骨与关节损伤基础实验 basic experiments of bone and joint injury • 上一篇    下一篇

膝关节液pH值与痛风结晶的形成

肖  颖，张思容，唐志宏，邹国耀，李  政，刘瑞端，刘  磊   

  1. 桂林医学院附属医院骨外科，广西壮族自治区桂林市  541001
  • 收稿日期:2011-02-11 修回日期:2011-05-14 出版日期:2011-06-25 发布日期:2011-06-25
  • 通讯作者: 唐志宏，硕士生导师，桂林医学院附属医院骨外科，广西壮族自治区桂林市 541001
  • 作者简介:肖颖★，男，1977年生，湖南省邵东县人，汉族，2008年南方医科大学毕业，硕士，主治医师，主要从事脊柱骨病，骨与关节损伤方面的研究。 39668731@qq.com
  • 基金资助:

    广西壮族自治区教育厅科研项目(200911LX302)；广西壮族自治区卫生厅自筹项目(2009037)；桂林市科学研究与技术开发技术项目(20090204)。

Meaning of pH value of the knee joint fluid in the crystal formation of gout

Xiao Ying, Zhang Si-rong, Tang Zhi-hong, Zou Guo-yao, Li Zheng, Liu Rui-duan, Liu Lei   

  1. Department of Orthopaedics and Spine Surgery, Affiliated Hospital of Guilin Medical University, Guilin  541001, Guangxi Zhuang Autonomous Region, China
  • Received:2011-02-11 Revised:2011-05-14 Online:2011-06-25 Published:2011-06-25
  • Contact: Tang Zhi-hong, Master’s supervisor, Department of Orthopaedics and Spine Surgery, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China
  • About author:Xiao Ying★, Master, Attending physician, Department of Orthopaedics and Spine Surgery, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China 39668731@qq.com
  • Supported by:

    the Scientific Research Project of Guangxi Education Bureau, No. 200911LX302*; the Self-raised Project of Guangxi Health Bureau, No. 2009037*; Science Research and Technology Development of Guilin City, No. 20090204*

PDF

841

被引次数

10

摘要：

背景：引起痛风结晶析出的原因除了尿酸盐浓度升高之外还应有其他的影响因素。
目的：探讨膝关节液pH值在痛风结晶形成中的意义。
方法：选择2008-08/2010-12桂林医学院附属医院脊柱骨病外科因膝关节疾病就诊的患者40例，分为2组，实验组：关节镜检见关节内白垩样结晶沉积者。对照组：关节镜检关节内无明显白垩样结晶形成。其中实验组膝关节液25份，对照组膝关节液15份。检测并比较两组患者的关节液pH值。
结果与结论：实验组pH值7.8±0.2，对照组pH值8.5±0.3。镜检有痛风结晶形成的膝关节液pH值较无痛风结晶形成的膝关节液pH值明显偏低，差异有显著性意义(P < 0.001)。提示有痛风结晶形成的膝关节液pH值较无痛风结晶形成的膝关节液pH值明显偏酸性，膝关节液pH值降低是痛风结晶析出的危险因素之一。

关键词: 膝关节液, pH值, 痛风性关节炎, 结晶, 尿酸

Abstract:

BACKGROUND: There should be other factors influencing crystallization of gout besides increase of uric acid concentration
OBJECTIVE: To explore the meaning of pH value of the knee joint fluid in the crystal formation of gout.
METHODS: We tested and compared the pH values of experiment group (25 hyperuricemia patients, with gout crystals in joint fluid) and control group (15 hyperuricemia patients, without gout crystals in joint fluid).
RESULTS AND CONCLUSION: The pH value of experiment group (7.8±0.2) was less than that of control group (8.6±0.3). The pH value of the knee joint fluid of patients with gout crystals in their knee joint was significantly lower than that of patients without gout crystals in their knee joint (P < 0.001). The lower pH value of the knee joint fluid, the more possibility of gout crystals. Low pH value of the knee joint fluid is one of the risk factors for crystallization of gout.

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