中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (33): 6184-6187.doi: 10.3969/j.issn.1673-8225.2010.33.025

• 组织构建与中医药 tissue construction and traditional Chinese medicine • 上一篇    下一篇

退行性膝骨关节病中医辨证分型的聚类分析

刘  渊1，牛  维2   

  1. 1广州中医药大学，广东省广州市  510405；2广州中医药大学第三临床医学院，广东省广州市  510405
  • 出版日期:2010-08-13 发布日期:2010-08-13
  • 作者简介:刘 渊☆，男，1980年生，新疆维吾尔自治区乌鲁木齐市人，汉族，广州中医药大学在读博士，主要从事骨关节病的研究。 liuyuanram@163.com

Cluster analysis of degenerative osteoarthropathy using traditional Chinese medicine syndrome types

Liu Yuan1, Niu Wei2   

  1. 1 Guangzhou University of Traditional Chinese Medicine, Guangzhou  510405, Guangdong Province, China; 2 Third Clinical College of Guangzhou University of Traditional Chinese Medicine, Guangzhou  510405, Guangdong Province, China
  • Online:2010-08-13 Published:2010-08-13
  • About author:Liu Yuan☆, Studying for doctorate, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, Guangdong Province, China liuyuanram@163.com

PDF

467

被引次数

43

摘要：

背景：目前各医家对膝关节退行性骨关节病的理解与认识还不完善，对于病机、治法及证型等仍然存在一定的分歧，使得治疗时存在较大的差异，究其原因是对于中医证型分类及诊断的客观研究较少。因而运用聚类分析的数理统计方法深入研究证型分类，对于指导中医和中西医结合临床的治疗工作意义颇大。
目的：系统聚类分析了解膝关节退行性骨关节病中医证型分布的情况。
方法：根据膝关节退行性骨关节病患者的临床表现设计调查表，收集70例患者的中医症状、体征、舌象、脉象等四诊信息，运用系统聚类分析统计方法，结合临床专业知识，探索总结本病的中医证型特征。
结果与结论：膝关节退行性骨关节病病位在膝，与肝肾两脏关系密切，病机以肝肾亏虚、风寒湿痹为主，系统聚类分析结果显示本病可大致分为3类证型:第1类以肝肾亏虚表现为主；第2类以风寒湿痹表现为主；第3类以气滞血瘀表现为主。结果表明肝肾亏虚为主兼以风寒湿痹是膝关节退行性骨关节病的基本证型，聚类分析可用于疾病的证候分类。

关键词: 膝骨关节病, 中医证型, 肝肾亏虚, 风寒湿痹, 气滞血瘀, 聚类分析

Abstract:

BACKGROUND: Degenerative osteoarthropathy is a commonly and frequently occurring disease in clinic, but most doctors have different comprehension and cognition at present, especially in pathogenesis, therapy and different symptom types of traditional Chinese medicine (TCM). The most important reason is lack of objective research in different symptom types and diagnosis in this disease. Therefore, it is significant to investigate syndrome classification using cluster analysis.
OBJECTIVE: To investigate the distribution trait in degenerative osteoarthropathy according to different symptom types of TCM.
METHODS: The questionnaire was designed according to the clinical manifestations in degenerative osteoarthropathy patients. A total of 70 patients including Chinese medicine symptoms, clinical signs, tongue, pulse and other diagnostic messages were collected and analyzed using Hierachical cluster analysis statistical method and combined with clinical knowledge, we hope to discover the characteristics of different symptom type of TCM in this disease.
RESULTS AND CONCLUSION: Degenerative osteoarthropathy occurred in the knee articulation, which has close relationship with the liver and kidney, and the main pathogenesise were deficiency of the liver and kidney and arthralgia caused by wind, cold and dampness. According to the result of Hierachical cluster analysis, the disease could be divided into three categories syndrome: The first symptom was deficiency of the liver and kidney; the second symptom was arthralgia caused by wind, cold and dampness; the last symptom was blood stasis and vital energy retardation. The findings demonstrated that cluster analysis statistical method can be used for classification of disease syndromes. 

中图分类号: