中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (30): 5581-5585.doi: 10.3969/j.issn.1673-8225.2010.30.018

• 数字化骨科 digital orthopedics • 上一篇    下一篇

基于生物力学性能的血管内支架弧梁单元结构优化设计

劳永华，支晓兴，林泽枫，李小您，岑人经，黄岳山   

  1. 华南理工大学生物科学与工程学院，广东省广州市     510006
  • 出版日期:2010-07-23 发布日期:2010-07-23
  • 通讯作者: 黄岳山，博士，副教授，华南理工大学生物科学与工程学院，广东省广州市 510006 bmbyshan@scut.edu.cn
  • 作者简介:劳永华☆，男，1978年生，广西壮族自治区北海市人，汉族，华南理工大学生物科学与工程学院在读博士，讲师，主要从事生物力学和生物系统建模与仿真研究。 yhlao@scut.edu.cn
  • 基金资助:

    华南理工大学中央高校基本科研业务费专项资金资助(2009ZM0075)：基于模糊优化的血管内支架生物力学结构设计。

Optimal design of intravascular stent arc-strut element structure based on biomechanical performance

Lao Yong-hua, Zhi Xiao-xing, Lin Ze-feng, Li Xiao-nin, Cen Ren-jing, Huang Yue-shan   

  1. School of Bioscience and Engineering, South China University of Technology, Guangzhou  510006, Guangdong Province, China
  • Online:2010-07-23 Published:2010-07-23
  • Contact: Huang Yue-shan, Doctor, Associate professor, School of Bioscience and Engineering, South China University of Technology, Guangzhou 510006, Guangdong Province, China bmbyshan@scut.edu.cn
  • About author:Lao Yong-hua☆, Studying for doctorate, Lecturer, School of Bioscience and Engineering, South China University of Technology, Guangzhou 510006, Guangdong Province, China yhlao@scut.edu.cn
  • Supported by:

    the Basic Scientific Research of Central High Institutes, South China University of Technology, No. 2009ZM0075*

PDF

730

被引次数

8

摘要：

背景：在扩张置入体内支撑血管的过程中血管内支架的结构需具备多种生物力学性能，支架结构可以通过综合多目标优化达到其整体性能的最佳状况。
目的：鉴于国内外的血管内支架结构设计，提取支架结构特征参数，进行生物力学指标的综合多目标优序分析。
方法：基于金属覆盖率、扩张最大支架内应力、最大扩张支架半径、轴向回缩率、径向回缩率等5种生物力学性能的分析，使用ADINA有限元软件建立了81种不同周向单元数、梁宽和单元轴长的支架闭口、平行和开口弧梁单元结构，并使用无量纲化和多目标优序法分析支架性能。
结果与结论：结果显示，可设计以单元轴长较大的闭口和平行弧梁单元为主、具有较小的均匀弧梁宽度的闭口、平行和开口弧梁混合单元结构。实验结果对血管内支架的结构设计和力学性能评价体系具有重要的指导意义。

关键词: 血管内支架, 生物力学, 弧梁单元, 多目标优化, 结构设计

Abstract:

BACKGROUND: Support the expansion of blood vessels in the implanted process of requires stent structure with complex biomechanical properties. The structure can achieve optimal overall performance by integrated multi-objective optimization.
OBJECTIVE: Based on designs of various intravascular stent structures, the features parameters were extracted for optimization analysis of biomechanics.
METHODS: Based on the analysis of biomechanical behavior: metal-based coverage, the maximal stent stress of expansion, maximal stent radius of expansion, axial recoil rate, radial recoil rate, finite element analysis software ADINA was used to establish 81 stent structures of closed, parallel, and open-arc strut element with different circumstantial unit number, arc-strut width and axial length of the stent unit element; the non-dimensional method and multi-objective optimum ranking was used to analyze the stent biomechanical behavior.
RESULTS AND CONCLUSION: Results showed that mixture structure of stent with closed, parallel, and open-arc strut element can be designed, and that the structure possesses mainly large axial length of the stent’s closed, parallel strut element and small arc-strut width uniformly. It is significantly important for the stent structural design and mechanical behavior evaluation system.

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