Hypotoxicity infection with sinus formation after tibial plateau and ankle fracture fixation: effects of orally taking rifampicin and ciprofloxacin with transfer of skin flap

doi:10.3969/j.issn.2095-4344.2014.44.05

Abstract

Abstract:

BACKGROUND: Recently, there are many documents all over the world reporting hypotoxicity infection after fracture internal fixation surgery, but reports are different on whether it is necessary for chronic hypotoxicity infection internal fixation removal post surgery. There are no fixed judgment criteria of curative effects, which leads to inexact conclusion of treatment method.
OBJECTIVE: To observe the curative effects of taking rifampicin and ciprofloxacin with transfer of skin flap in the treatment of chronic hypotoxicity infection with sinus formation after fracture surgery on tibial plateau and ankle.
METHODS: A total of 56 cases of chronic hypotoxicity infection after fracture surgery of tibial plateau and ankle were collected from September 2005 to December 2012. 30 cases in the therapy group were treated with levofloxacin and rifampicin with transfer of skin flap. 26 cases in the control group were treated with conventional intravenous antibiotics with local debridement to remove internal fixation. In both groups, the course of disease was 3 to 6 months. The erythrocyte sedimentation rate, kidney function and radiographic indices were reviewed every 1 to 3 months, and curative effects were evaluated.
RESULTS AND CONCLUSION: During the follow-up visit of 6-24 months, no recurrence happened to the cured and improved patients. In the therapy group, 24 cases were cured, 4 cases were improved, and 2 cases were invalid, with a total effective rate of 93%. In the control group, 11 cases were cured, 6 cases were improved and 9 cases were invalid with the total effective rate of 65%.χ2 test showed that therapeutic effects were significantly better in the therapy group than in the control group (P < 0.05). These data indicated that rifampicin and ciprofloxacin with transfer of skin flap for chronic hypotoxicity infection with sinus formation after fracture surgery of tibial plateau and ankle showed good curative effects.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

全文链接：

Key words: internal fixators, tibia, fractures, bone, follow-up studies

CLC Number:

R318

Zhang Bo, Zhao Jin-long, Ouyang Zhen, Yu Yang, Wu Tao, Song Yong-cai, Li Wu-jian, Liu Ji-chao, Yin Wei, Yang Li-feng, Liu Feng-hu, Yang Bin-hui. Hypotoxicity infection with sinus formation after tibial plateau and ankle fracture fixation: effects of orally taking rifampicin and ciprofloxacin with transfer of skin flap[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(44): 7077-7082.

Figures/Tables 4

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