Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (12): 1886-1890.doi: 10.3969/j.issn.2095-4344.3782

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Anatomical and morphological characteristics of knee joint in hemophilic arthritis patients with three-dimensional CT and X-ray films

Pei Tianlong, Wang Yongkang, Wu Wenjie, Zhao Hong, Wang Longsheng    

  1. Department of Radiology, Second Affiliated Hospital of Anhui Medical University, Hefei 236300, Anhui Province, China
  • Received:2020-06-19 Revised:2020-06-24 Accepted:2020-08-04 Online:2021-04-28 Published:2020-12-25
  • Contact: Wang Longsheng, Master, Chief physician, Department of Radiology, Second Affiliated Hospital of Anhui Medical University, Hefei 236300, Anhui Province, China
  • About author:Pei Tianlong, Master candidate, Department of Radiology, Second Affiliated Hospital of Anhui Medical University, Hefei 236300, Anhui Province, China
  • Supported by:
    the Provincial Quality Engineering Project in Colleges and Universities in 2019, No. 2019jyxm1005 (to WLS)

Abstract: OBJECTIVE: To provide reference data for the design of knee prosthesis for hemophilic arthritis patients through the measurement of knee three-dimensional CT anatomical morphological parameters and X-ray. 
METHODS: A retrospective analysis of 46 cases of knee thin-section CT images and X-ray anteroposterior stand-up radiograph of lower limbs was conducted, including 23 cases of hemophilia patients and 23 cases of ordinary patients. Age, sex, height, body mass and body mass index were collected. Those patients were measured by three-dimensional software for the femoral lateral anteroposterior diameter, width of lateral condyle, femoral medial anteroposterior diameter, width of medial condyle, tibial anteroposterior diameter, tibial mediolateral width, tibial medial anteroposterior line, and tibial lateral anteroposterior. The following measurements were obtained on anteroposterior stand-up radiograph of lower limbs: the anatomical femoral-tibial angle, lateral distal femoral angle, and medial proximal tibial angle. The morphological differences between the two groups were compared and analyzed.
RESULTS AND CONCLUSION: (1) The tibial medial anteroposterior line, tibial anteroposterior diameter, the anatomical femoral-tibial angle, and medial proximal tibial angle were smaller in the hemophiliac group than those in the ordinary group, and there were significant difference (P < 0.05). (2) The femoral lateral anteroposterior diameter and femoral medial anteroposterior diameter of the hemophiliac group were both smaller than those in the ordinary group; while width of lateral condyle and width of medial condyle were larger in the hemophiliac group than those in the ordinary group (P < 0.001). (3) The results showed that the anatomical morphology of proximal tibia and distal femur in the hemophiliac group was different from that in the ordinary group. The proximal medial wear of tibia was more severe in the hemophiliac group than in the control group, while the distal medial and lateral femoral condyles were wider in the hemophiliac group than in the ordinary group. In addition, the aspect ratio of the distal femur is relatively small.


Key words: bone, knee joint, total knee arthroplasty, hemophilia, anatomical morphology, tibia, femur

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