Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (14): 2645-2647.doi: 10.3969/j.issn.1673-8225.2012.14.036

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Treatment of nine patients with amyotrophic lateral sclerosis by autologous peripheral blood mononuclear cells transplantation: change of short-term effect  

Sun Da-yong, Han Jie, Li Xue-jiao, Liu Jing, Song Chun-li   

  1. Department of Neurology, the First Affiliated Hospital of Dalian Medical University, Dalian  116011, Liaoning Province, China
  • Received:2011-07-19 Revised:2011-09-20 Online:2012-04-01 Published:2012-04-01
  • Contact: Han Jie, Doctor, Chief physician, Department of Neurology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
  • About author:Sun Da-yong★, Master, Attending physician, Department of Neurology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China hastendys@sina.com

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Abstract:

BACKGROUND: At present, there are some clinical reports about the treatment of amyotrophic lateral sclerosis (ALS) by transplantation of autologous bone marrow nucleated cells, olfactory cells and umbilical cord blood-derived stem cells.
OBJECTIVE: To evaluate clinical effect of peripheral blood mononuclear cells transplantation on the treatment of 9 ALS patients.
METHODS: The changes of neurological function (Norris, FIM, Bathel score) and electromyogram (EMG) changes of 9 ALS patients were evaluated by before-after self control study at the 1st, 3rd, 6th months after peripheral blood mononuclear cells transplantation.
RESULTS AND CONCLUSION: After peripheral blood mononuclear cells transplantation, the symptom was improved, neurological scores were significantly higher than pre-transplant, short-term effect was obvious and the EMG showed improvement trend. The results showed that peripheral blood mononuclear cells transplantation has valid short-term effect on improving the neurological dysfunction of ALS patients.

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