Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (14): 2505-2508.doi: 10.3969/j.issn.1673-8225.2012.14.007

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Local injection of bone marrow mesenchymal stem cells versus triamcinolone acetonide for treatment of Achilles tendinitis in rabbits

Qiu Chao, Hong Jian-jun, Mao Cheng-huang, Lu Xiao-lang   

  1. Department of Orthopedics, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou  325000, Zhejiang Province, China
  • Received:2011-12-16 Revised:2012-03-03 Online:2012-04-01 Published:2012-04-01
  • Contact: author: Hong Jian-jun, Master, Chief physician, Associate professor, Master’s supervisor, Department of Orthopedics, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China hjjwz@163.com
  • About author:Qiu Chao★, Studying for master’s degree, Physician, Department of Orthopedics, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China hynh24@yahoo.com.cn

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Abstract:

BACKGROUND: It remains to be disputed to apply long-lasting glucocorticoid for partial closure theray of Achilles tendonitis.
OBJECTIVE: Bone marrow mesenchymal stem cells and long-lasting triamcinolone acetonide were respectively injected into the achilles tendon of a rabbit model of Achilles tendonitis to dynamically observe related indices and investigate the effects of bone marrow mesenchymal stem cells and long-lasting triamcinolone acetonide on tissue structure and mechanical performance of Achilles tendon with tendonitis.
METHODS: Sixty rabbit models of unilateral Achilles tendinitis were randomly divided into four groups. Two groups were locally administered bone marrow mesenchymal stem cells and triamcinolone acetonide respectively once, and the remaining two groups were locally administered bone marrow mesenchymal stem cells and glucocortocoid respectively twice with a time interval of 2 weeks.
RESULTS AND CONCLUSION: Compared with triamcinolone acetonide once group, rabbits in the bone marrow mesenchymal stem cells once or twice groups, rabbits exhibited regular, dense tendon bundles, increased fibroblasts, increased hydroxyproline content in the tendon tissue and increased maximum load strength of tendon (P < 0.05), in particular twice injections (P < 0.05). These findings suggest that local repeated injections of bone marrow mesenchymal stem cells exhibit better therapeutic effects than long-lasting triamcinolone acetonide application in treatment of Achilles tendinitis.

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