Abstract:

BACKGROUND: Studies have shown that autologous bone marrow mononuclear cells transplantation can treat the diabetic peripheral neuropathy (DPN) of lower limb. It can improve the clinical symptom by promoting the angiogenesis and increasing vascular endothelial growth factor and neurotrophic factor.
OBJECTIVE: To evaluate the clinical efficacy of autologous bone marrow mononuclear cells transplantation for the treatment of DPN of lower limb.
METHODS: 60 lower limbs of 30 patients with DPN were divided into two groups by treatment method, 30 lower limbs received autologous stem cells transplantation (treatment group), 30 lower limbs did not receive autologous stem cells transplantation as control group (control group).
RESULTS AND CONCLUSION: At 4 weeks after transplantations, the total efficiency rate in treatment group was higher than that in control group (P < 0.05). After treatment, the TSS in two groups was significantly decreased, and the TSS in treatment group was lower than that in the control group (P < 0.01). The sensory nerve conduction velocity (SCV) and motor nerve conduction velocity (MCV) of tibial nerve and common peroneal nerve in treatment group were faster than that in the control group (P < 0.01), no related complication or adverse effects were observed in all patients. Autologous bone marrow stem cells transplantation has a good clinical efficacy on the treatment of lower limb DPN.