Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (1): 171-174.doi: 10.3969/j.issn.1673-8225.2012.01.037

Previous Articles     Next Articles

Effect of umbilical cord blood mesenchymal stem cells transplantation on immune function of spinal cord injury patients

Zhao Ning1, Yang Wan-zhang1, Zhang Min1, Sheng You-xiang1, Tang Ying2    

  1. 1Department of Rehabilitation Medicine, Shenzhen Nanshan Affiliated Hospital of Guangdong Medical University, Shenzhen  518052, Guangdong Province, China; 2Department of Rehabilitation Medicine, Longgang Central Hospital of Shenzhen, Shenzhen  518000, Guangdong Province, China
  • Received:2011-07-28 Revised:2011-09-15 Online:2012-01-01 Published:2012-01-01
  • Contact: Yang Wan-zhang, Doctor, Professor, Chief physician, Master’s supervisor, Department of rehabilitation medicine, Shenzhen Nanshan Affiliated Hospital of Guangdong Medical University, Shenzhen 518052, Guangdong Province, China
  • About author:Zhao Ning★, Master, Attending physician, Department of Rehabilitation Medicine, Shenzhen Nanshan Affiliated Hospital of Guangdong Medical University, Shenzhen 518052, Guangdong Province, China zhloo7692@yahoo.com.cn
  • Supported by:

    Foundation of Science and Technology Bureau of Shenzhen, No. 200405219*  

PDF

451

Cited

2

Abstract:

BACKGROUND: Mesenchymal stem cells (MSCs) transplantation has certain immunogenicity. However, there was no in-depth and system reports about the effect of MSCs transplantation on spinal cord injury patient’s immune function.
OBJECTIVE: To observe the effects of umbilical cord blood MSCs (UCB-MSCs) transplantation on immune function of spinal cord injury (SCI) patients.
METHODS: Sixty-one spinal cord injury (SCI) patients were treated by intervenous drop infusion and lumbar subarachnoid space puncture to UCB-MSCs. Flow-cytometry and immunoturbidimetry (ITM) were used to detect the content of T lymphocytic subgroup and immune globulin and the alexinic in plasma of all the patients prior and post-transplantation.
RESULTS AND CONCLUSION: Compare with pre-transplantation, the content of CD3+, IgA and IgG was decreased and the differences were significant; The content of CD4+, CD8+, CD4+/CD8+, IgM, C3 and C4 was also changed and the differences were not significant. It indicates that UCB-MSCs transplantation could not activate the immunological response of cell and humoral immunity, so the transplantation is safety. Negative accommodation is exist, but the relevant indicators need a further improvement, expand samples, and clearly relevant mechanism. 

CLC Number: