Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (1): 167-170.doi: 10.3969/j.issn.1673-8225.2012.01.036

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Genetic engineering and cell engineering for repair of damaged atrioventricular conduction or construction of artificial atrioventricular bypass

Dong Hao1, Li Ping1, Li Xuan2   

  1. 1 南昌大学第二附属医院心血管内科，江西省南昌市  330006；2南昌大学医学院，江西省南昌市 330006
  • Received:2011-06-12 Revised:2011-07-10 Online:2012-01-01 Published:2012-01-01
  • Contact: Li Ping, Doctor, Professor, Chief physician, Master’s supervisor, Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang 330066, Jiangxi Province, China lipingsydney@163.com
  • About author:Dong Hao★, Studying for master’s degree, Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang 330066, Jiangxi Province, China tinymice@163.com
  • Supported by:

     the National Natural Science Foundation of China, No. 30960125*

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Abstract:

BACKGROUND: Using cell-engineering and gene technology to treat bradyarrhythmia has features such as not requiring external energy resource and not being regulated by the neural hormone. It is a way which is more similar to the nature human body. These advantages are incomparable to drugs and electronic pacing.
OBJECTIVE: To review the development and existing problems in using genetic engineering and cell engineering to treat bradyarrhythmia.
METHODS: A computer online search was performed to retrieve papers published between 2000-01 and 2011-06 in PubMed and CNIK database.
RESULTS AND CONCLUSION: Genetic engineering healing bradyarrhythmia paid close attention to β2-adrenergic receptor and Kir2.1 first. And HCN, AC-VI and Tbx3 are the most popular ones in recent research. The stem cell transplantations including the stem cell modified by gene, the combination of cells, iPS and CSCs have displayed their great potential in the treatment of bradyarrhythmia. The obvious alternative here would be to build an atrioventricular bypass tract to permit the normal sinus nodal impulse to propagate to the ventricle. However, there are still a lot of key issues to deal with, such as the optimization of the atrioventricular delay, the program design of automatically responding and the position of the artificial bypass tract.
 

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