Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (53): 9981-9985.doi: 10.3969/j.issn.1673-8225.2011.53.025

Previous Articles     Next Articles

Correlation between renal arterial hemodynamic alterations and renal functions evaluated by color Doppler ultrasound using a rabbit renal ischemia reperfusion model

Xuan Ji-qing1, Peng Li-qing1, Li Ming-xing1, Li Kun-ping2, Luo Zhi-jian1   

  1. 1Department of Ultrasound, Affiliated Hospital of Luzhou Medical College, Luzhou   646000, Sichuan Province, China
    2Department of Ultrasound, Zhuhai People’s Hospital, Zhuhai   519000, Guangdong Province, China
  • Received:2011-08-25 Revised:2011-09-16 Online:2011-12-31 Published:2011-12-31
  • Contact: Li Ming-xing, Department of Ultrasound, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China lmx526@sina.com
  • About author:Xuan Ji-qing★, Master, Physician, Department of Ultrasound, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China alice11@yeah.net
  • Supported by:

    a grant from Health Department of Sichuan Province, No. 070243*

PDF

585

Abstract:

BACKGROUND: Previous diagnosis of renal ischemia reperfusion mainly depends on biochemical and pathological examination. Color Doppler flow imaging (CDFI) can mini-invasively rapidly display renal blood flow changes following renal ischemia/reperfusion injury. 
OBJECTIVE: To evaluate rabbit renal arterial hemodynamical changes after renal ischemia reperfusion using CDFI, and analyze the correlation between arterial hemodynamical changes and renal function indices including blood urea nitrogen (BUN) and creatinine (Cre).
METHODS: Fifty-six rabbits were randomly divided into normal control group, ischemia reperfusion group and sham operation group. Rabbits were established into renal ischemia reperfusion models in the ischemia reperfusion group. Rabbits in the sham operation group underwent resection of the right kidney. No treatment was performed in the control group. According to different time points, three subgroups were used in the former two groups.
RESULTS AND CONCLUSION: With aggravation of renal ischemia reperfusion injury, the systolic velocity, pulsatility index, resistance index and BUN and Cre were gradually increased and reached the peak at 24 hours. Hemodynamical changes first appeared in the interlobar artery. Resistance index is the most sensitive index to reflect the degree of renal ischemia reperfusion injury. CDFI is an effective method to evaluate renal ischemia/reperfusion injury degree.

CLC Number: