Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (51): 9565-9569.doi: 10.3969/j.issn.1673-8225.2011.51.016

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Preparation of nano-hydroxyapatite/aliphatic polyester-amide electrospun ultrafine fiber and its biocompatibility

Deng Xia1, Xia Xi2, Chen Zhi-qing3   

  1. 1Department of Stomatology, Nuclear of Industry 416 Hospital, Chengdu  610051, Sichuan Province, China
    2Department of  Prosthodontics, College of Stomatology, Chongqing University of Medical Science, Chongqing  400015, China
    3Department of Dental Materials, West China School of Stomatology, Sichuan University, Chengdu  610041, Sichuan Province, China
  • Received:2011-06-18 Revised:2011-07-15 Online:2011-12-17 Published:2011-12-17
  • Contact: Xia Xi, Master, Attending physician, Department of Prosthodontics, College of Stomatology, Chongqing University of Medical Science, Chongqing 400015, China xixi_xia@163.com
  • About author:Deng Xia☆, Doctor, Attending physician, Department of Stomatology, Nuclear of Industry 416 Hospital, Chengdu 610051, Sichuan Province, China xiad520@sina.com
  • Supported by:

    the National High-Tech Research and Development Program of China (863 Program), No. 200ZAA326080*

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Abstract:

BACKGROUND: Bioactive ceramics can be introduced into ultrafine fibers by electrospinning method. The electrospun composite which simulates the structure and biological function of native extracellular matrix is a new branch in bone tissue engineering research. 
OBJECTIVE: To prepare the nano-hydroxyapatite/aliphatic polyester-amide electrospun ultrafine fibers (nHA/PEA) and to evaluate the biocompatibility.
METHODS: The nHA/PEA scaffold was prepared by electrospinning technology and characterized with X-ray diffraction, scanning electron microscope and energy-dispersive X-ray spectroscopy. Moreover, osteoblasts were cultured on the surface of nHA/PEA scaffold and the morphology of osteoblasts was investigated. 
RESULTS AND CONCLUSION: Good cell adhesion and proliferation manner was observed on the fibrous scaffold, indicating that the cellular biocompatibility of the composite scaffold is preliminarily confirmed. It is expected that the electrospun nHA/PEA composite scaffold can be a potential biomimetic extracellular matrix biomaterial for bone tissue engineering.

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