Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (50): 9453-9456.doi: 10.3969/j.issn.1673-8225.2011.50.035

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Expression of Toll-like receptor 4 in rat periodontal ligament during orthodontic tooth movement

Nie Jing1, Zhong Liang-jun2, Li Xiao-Bing3, Lin Bao-Shan3, Qian Xu3, Qian Ya-Jing1   

  1. 1Department of Orthodontics, First Teaching Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
    2Department of Stomatology, the  Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang Province, China
    3Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2011-09-07 Revised:2011-11-09 Online:2011-12-10 Published:2011-12-10
  • Contact: Zhong Liang-jun, Chief physician, Department of Stomatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang Province, China zymdxx@163.com
  • About author:Nie Jing★, Master, Department of Orthodontics, First Teaching Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China niejing202@sohu.com
  • Supported by:

    the Youth Foundation of the First Affiliated Hospital of Xinjiang Medical University, No. 2010-QN-09*

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Abstract:

BACKGROUND: Extensive research has been done on the function of the periodontal ligament under the orthodontic force. However, there are no reports regarding the expression of Toll-like receptor 4 in rat periodontium during orthodontic tooth movement.
OBJECTIVE: To investigate the expression of Toll-like receptor 4 in rat periodontium during orthodontic tooth movement.
METHODS: Rat orthodontic tooth movement model was constructed using NiTi extension spring with the force value of 50 g. The orthodontic periodontium was collected on the 1st, 3rd, 5th, 7th, 10th and 14th days after exerting force to detect the expression of Toll-like receptor 4.
RESULTS AND CONCLUSION: According to immunofluorescence staining, the expression of Toll-like receptor 4 in the periodontal tissues increased on the 1st day after exerting force, and reached highest level on the 5th day; then fell to the initial level on the 14th day. Thus the expression of Toll-like receptor 4 is evoked by orthodontic force, and it may play a role in periodontal remodeling.

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