Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (50): 9457-9461.doi: 10.3969/j.issn.1673-8225.2011.50.036

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Early application of sodium tanshinoneⅡA sulfonate can depress hypertrophic scar of rabbit ear

Zhang Jian-hua, Ou Bin-xian, Meng Cheng-yue   

  1. Department of Burn and Plastic Surgery, First Affiliated Hospital of Gaungxi Medical University, Nanning  530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-06-19 Revised:2011-10-13 Online:2011-12-10 Published:2011-12-10
  • Contact: Meng Cheng-yue, Chief physician, Department of Burn and Plastic Surgery, First Affiliated Hospital of Gaungxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China mcy8060@126.com
  • About author:Zhang Jian-hua★, Master, Physician, Department of Burn and Plastic Surgery, First Affiliated Hospital of Gaungxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China 347313009@qq.com
  • Supported by:

    the Natural Science Foundation of Guangxi, No. Guikezi0728129*

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Abstract:

BACKGROUND: Sodium tanshinoneⅡA sulfonate (STS) play effects on anti-oxidant, and depression of fibration. 
OBJECTIVE: To investigate the effect of early injection of STS on hypertrophic scar (HS) of rabbit ear.
METHODS: Scar model were established by removing the skin and perichondrium in rabbits ears on facies ventralis. STS    0.05 mg, 0.1 mg, 0.2 mg (or 40μl normal saline, respectively, experimental groups), normal saline 40 μL(control group) were injected into early rabbits ears scars, once a week, 3 weeks all together.
RESULTS AND CONCLUSION: After 3 weeks STS injection, the hyperplasia and the thickness were decreased; the quantity of collagen fiber and vascular in scar tissue section was decreased in experimental group detected by hematoxylin-eosin staining. The collagen fiber area in scar tissue section was decreased by Masson staining and the amount and the volume of fibroblast were decreased under electron microscope. That indicated that early STS injection could depress HS in rabbits scar ears.

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