Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (41): 7737-7741.doi: 10.3969/j.issn.2095-4344.2012.41.028

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Application prospect of bone marrow mesenchymal stem cells in the treatment of glioma

Fan Cun-gang, Zhang Qing-jun   

  1. Department of Neurosurgery, People’s Hospital of Peking University, Beijing 100044, China
  • Received:2011-11-18 Revised:2011-12-16 Online:2012-10-07 Published:2012-10-07
  • Contact: Zhang Qing-jun, Chief physician, Professor, Doctoral supervisor, Department of Neurosurgery, People’s Hospital of Peking University, Beijing 100044, China zhangqjhb@yahoo.com.cn
  • About author:Fan Cun-gang☆, Studying for doctorate, Attending physician, Department of Neurosurgery, People’s Hospital of Peking University, Beijing 100044, China fancungang@yahoo.com.cn

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Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) display extensive tropism for glioma and exert anti-tumor effect on glioma.
OBJECTIVE: To investigate the therapeutic prospects of BMSCs in the treatment of glioma on the basis of reviewing related articles.
METHODS: The first author retrieved CNKI database and PubMed database for concerning articles. The key words were “mesenchymal stem cells, bone marrow, glioma” in Chinese and English. A total of 51 articles were retrieved primarily by computer, and 29 articles were finally included for review according to inclusion criteria.
RESULTS AND CONCLUSION: BMSCs have a strong migratory capacity towards glioma. In addition, BMSCs can inhibit the proliferation of glioma and induce the glioma cells differentiation. Moreover, the BMSCs carrying suicide genes, immune genes, tumor necrosis factor and oncolytic virus can exert stronger antitumor effect on glioma. BMSCs may serve as a promising vector for gene-targeted glioma therapy.

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