Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (47): 8773-8776.doi: 10.3969/j.issn.1673-8225.2011.47.009

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Fibrin glue combined with bone marrow mesenchymal stem cells to repair multi-layer soft tissue defects in rabbits

Xie Fu-rong1, Lin Chun-bo1, Yan Dong-xue2, Yang Yuan1   

  1. 1Orthopaedic Hospital of Guangxi, Nanning  530012, Guangxi Zhuang Autonomous Region, China
    2Affiliated Hospital of Guilin Medical College, Guilin  541001, Guangxi Zhuang Autonomous Region, China
  • Received:2011-04-07 Revised:2011-07-08 Online:2011-11-19 Published:2011-11-19
  • Contact: Yang Yuan, Professor, Orthopaedic Hospital of Guangxi, Nanning 530012, Guangxi Zhuang Autonomous Region, China Correspondence to: Yan Dong-xue, Associate professor, Affiliated Hospital of Guilin Medical College, Guilin 541001, Guangxi Zhuang Autonomous Region, China
  • About author:Xie Fu-rong, Associate chief physician, Orthopaedic Hospital of Guangxi, Nanning 530012, Guangxi Zhuang Autonomous Region, China Xiefr95628@163.com
  • Supported by:

    grants from Guangxi Science and Technology Bureau, No. 10124001B-55*, 0816004-15*, 0728077*, 0832157*, 0592007-1G*

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Abstract:

BACKGROUND: Fibrin glue meeting the physical structure of the soft tissue is appropriately used as a carrier material to repair soft tissue defects.
OBJECTIVE: To investigate the feasibility of bone marrow mesenchymal stem cells combined with fibrin glue to repair soft tissue defects.
METHODS: Soft tissue defects were made on the deep thigh muscle layer of New Zealand white rabbits with diameter greater than 3 cm. Twenty-four model rabbits were randomly divided into three groups: in experimental group, allogeneic bone marrow mesenchymal stem cells combined with fibrin glue were injected into the soft tissue defects; in control group, the fibrin glue was injected into soft tissue defects of rabbits; in model group, nothing was injected into soft tissue defects of rabbits.
RESULTS AND CONCLUSION: Wound contraction rates at 14 and 21 days after operation were the experimental group > control group > the model group (P < 0.01); the healing time was the experimental group < control group < model group (P < 0.01). The results showed that the fibrin glue combined with bone marrow mesenchymal stem cells can rapidly repair multi-layer soft tissue defects.

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