Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (42): 7827-7830.doi: 10.3969/j.issn.1673-8225.2011.42.009

Previous Articles     Next Articles

A hydrophilic polyurethane material with good blood compatibility

Lu Jin, Zhou Hui-juan, Shi Hui-ting, Qian Yu-feng, He Chun-li, Liang Cun-xia, Li Li   

  1. Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, Nanjing  210097, Jiangsu Province, China
  • Received:2011-02-17 Revised:2011-05-09 Online:2011-10-15 Published:2011-10-15
  • Contact: Li Li, Doctor, Professor, Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, Nanjing 210097, Jiangsu Province, China lili3@njnu.edu.cn
  • About author:Lu Jin, Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, Nanjing 210097, Jiangsu Province, China lujin1989810@ gmail.com
  • Supported by:

    the National Natural Science Foundation of China, No. 20874047*; the Natural Science Foundation of Jiangsu Province, No. BK2008434*; the Natural Science Foundation of Jiangsu Provincial Universities, No. 10KJA430026*; Dominant Discipline Construction Project of Jiangsu Provincial Universities*

PDF

509

Abstract:

BACKGROUND: When polyurethane materials are in contact with living organisms, they can cause adverse biological reactions, for example, forming thrombus and inflammation.
OBJECTIVE: To improve the hydrophilicity of polyurethane materials through a mixture of hydrophilic soft segments so as to obtain a polyurethane material with better anticoagulant properties.
METHODS: Polyurethane films were synthesized with polytetrahydrofuran and polyethylene glycol as mixed soft segments,   4, 4’-diphenylmethane diisocyanate as the hard segment, and then in the chain extender 1, 4-butanediol and the catalyst dibutyltin dilaurate conditions to obtain a series of polyurethane materials.
RESULTS AND CONCLUSION: The results showed that hydrophilic and blood compatibility properties of polyurethane films were enhanced, with the increase of the content of polyethylene glycol.

CLC Number: