Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (32): 6056-6059.doi: 10.3969/j.issn.1673-8225.2011.32.038

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Biological characteristics and clinical application of skin-derived precursor cells

Li Zong-zhe1, Li Yang1, Zong Zhao-wen2, Zhang Lian-yang2   

  1. 1The 17th Team of Students’ Group, Third Military Medical University of Chinese PLA, Chongqing  400038, China
    2State Key Laboratory of Trauma, Burns and Combined Injury, Department of Trauma and Injuries, Institute of Surgical Research, Daping Hospital, Third Military Medical University of Chinese PLA, Chongqing  400042, China
  • Received:2010-04-02 Revised:2011-07-14 Online:2011-08-06 Published:2011-08-06
  • Contact: Zhang Lian-yang, Professor, Chief physician, Doctoral supervisor, State Key Laboratory of Trauma, Burns and Combined Injury, Department of Trauma and Injuries, Institute of Surgical Research, Daping Hospital, Third Military Medical University of Chinese PLA, Chongqing 400042, China hpzhangly@163.com
  • About author:Li Zong-zhe☆, Studying for doctorate, the 17th Team of Students’ Group, Third Military Medical University of Chinese PLA, Chongqing 400038, China Zongzhe00@yahoo.com.cn
  • Supported by:

    Major Project of Chinese National Programs for Fundamental Research and Development (973 Program), No. 2011CB964701*; Automatic Research Fund of State Key Laboratory of Trauma, Burns and Combined Injury, No.SKLZZ200817*

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Abstract:

BACKGROUND: Skin-derived precursor cells (SKPs) are a novel population of neural crest-related precursor cells that can be isolated from embryonic and adult skin, and have multiple differential potential.
OBJECTIVE: To review the cultivation, separation, biological characteristics and application prospects of SKPs.
METHODS: The PubMed database was searched for articles published from January 2001 to January 2011. The keywords were “skin-derived precursor cells, skin-derived precursors, SKPs”. The language of articles was limited to English.
RESULTS AND CONCLUSION: SKPs are rich in source, easily available and multi-potent. SKPs can differentiate into Schwann cells, neuronal cells and even islet-like cells that have in vitro and in vivo function. SKPs have a good prospect as an experimental and therapeutic resource for disease modelling and regenerative medicine. However, there are still many problems in application.

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