Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (32): 6051-6055.doi: 10.3969/j.issn.1673-8225.2011.32.037

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Advances of stem cells transplantation for spinal cord injury

Liu Chang-lu1, Wu Yan2   

  1. 1Second Affiliated Hospital of Inner Mongolia Medical College, Huhhot  010030, Inner Mongolia Autonomous Region, China
    2Inner Mongolia Medical College, Huhhot  010059, Inner Mongolia Autonomous Region, China
  • Received:2010-03-31 Revised:2011-04-10 Online:2011-08-06 Published:2011-08-06
  • Contact: Wu Yan, Doctor, Professor, Master’s supervisor, Inner Mongolia Medical College, Huhhot 010059, China yanw007@sina.com
  • About author:Liu Chang-lu★, Studying for master’s degree, Physician, Second Affiliated Hospital of Inner Mongolia Medical College, Huhhot 010030, Inner Mongolia Autonomous Region, China hhhtliuchanglu@163.com
  • Supported by:

    Talent Developing Foundation of Inner Mongolia Autonomous Region, No. 2009*; Stem Cells Innovation Team Foundation of Inner Mongolia Autonomous Region, No. 2009*

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Abstract:

BACKGROUND: Stem cell transplantation as the most promising treatment for spinal cord injury, has been confirmed in a large number of animal experiments and clinical trials.
OBJECTIVE: To review the related research progress of stem cell transplantation for spinal cord injury.
METHORDS: A computer-based online search of related articles were performed in CNKI and Medline database published from January 2006 to December 2010, with the key words of “Stem cells; Spinal cord injury; Cells transplantation” in Chinese and English, respectively. 494 articles were collected, and 24 were included.
RESULTS AND CONCLUSION: Studies show that transplanted cells can migrate, differentiate into neurons and secrete neural nutrients to promote nerve tissue repair and improve neural function. Embryonic stem cells have been used in the treatment of spinal cord injury, but the potential tumorigenicity limits its clinical application. Neural stem cells are theoretically preferred treatment of spinal cord injury, but this technique develops slowly because of strict separation and purification technology and expensive cost. Mesenchymal stem cell has rich sources, and simple sampling, with feasible autologous transplantation, which avoids the ethical problems and graft rejection. Currently mesenchymal stem cell has been identified as an ideal autologous stem cell transplantation source. With advancing cell transplantation, gene modification and tissue engineered scaffold transplantation for treatment of spinal cord injury, the application range and treatment effect of Schwann cells and olfactory ensheathing cells are also improved.

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