Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (32): 6047-6050.doi: 10.3969/j.issn.1673-8225.2011.32.036

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Transgenic neural stem cell transplantation for Parkinson’s disease: Possibility and feasibility

Ding Ji-gu   

  1. Human Anatomy Teaching, School of Basic Medicine, Xianning College, Xianning   437100, Hubei Province, China
  • Received:2011-03-09 Revised:2011-04-28 Online:2011-08-06 Published:2011-08-06
  • About author:Ding Ji-gu, Professor, Master’s supervisor, Human Anatomy Teaching, School of Basic Medicine, Xianning College, Xianning 437100, Hubei Province, China dingjigu@hotmail.com
  • Supported by:

    the Key Program of Department of Education of Hubei Province, No. D20092802*

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Abstract:

BACKGROUND: Which type of nerve cells neural stem cells differentiate into is not only decided by cell own gene regulation, but also influenced by the external signals.
OBJECTIVE: To review the biology characteristics, differentiation and transgenic transplantation of neural stem cells in treatment of Parkinson’s disease.
METHODS: A computer search of PubMed (1992-01/2009-12) and CNKI (2003-01/2010-12) for articles related to the biology characteristics, differentiation and transgenic transplantation of neural stem cells in treatment of Parkinson’s disease was performed by the fist author using the keywords of “neural stem cells (NSCs), neural stem cell transplant, Parkinson's Disease (PD)” in English and Chinese, respectively. Finally, 30 articles were included.
RESULTS AND CONCLUSION: Treatment of Parkinson’s disease with transgenic transplantation of neural stem cells is the most promising treatment option. Under the low oxygen condition, neural stem cells receiving transgenic culture can be induced highly to differentiate into dopaminergic neurons that provide a cell source for treatment of Parkinson’s disease. However, the biological characteristics and induced differentiation of neural stem cells needs further studies. Simultaneously, the biological safety during human body treatment gradually attracts more attentions, such as oncogenicity that is studied further.

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