Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (32): 5999-6002.doi: 10.3969/j.issn.1673-8225.2011.32.025

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Bone marrow mononuclear cell transplantation combined with core decompression treatment for early osteonecrosis: A three-dimensional gait analysis

Zhao De-wei1, Xie Hui2, Cui Da-ping3   

  1. 1Zhongshan Hospital, Dalian University, Dalian  116001, Liaoning Province, China
    2Graduate College of Dalian University, Dalian  116001, Liaoning Province, China
    3Zhongshan Hospital of Dalian University, Dalian  116001, Liaoning Province China
  • Received:2011-03-09 Revised:2011-04-13 Online:2011-08-06 Published:2011-08-06
  • Contact: Zhao De-wei, Professor, Zhongshan Hospital, Dalian University, Dalian 116001, Liaoning Province, China
  • About author:Zhao De-wei☆, Doctor, Professor, Zhongshan Hospital, Dalian University, Dalian 116001, Liaoning Province, China cuidaping@126.com

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Abstract:

BACKGROUND: Gait analysis provides an objective and accurate quantitative assessment for the orthopedic examination.
OBJECTIVE: To observe the gait kinematic characteristics and change rule of patients with early avascular necrosis of the femoral head following treatment of bone marrow mononuclear cell (BMMCs) transplantation combined with core decompression treatment.  
METHODS: Three-dimensional motion capture gait analysis was performed in 21 cases of early osteonecrosis undergoing BMMCs transplantation with core decompression. Before and 3, 6, 9, 12 months after treatment, step length, step width, angle of hip motion, kinematic data of hip angle acceleration in the 22 patients walking on the treadmill of 0° and 15°. Gait data of 33 healthy subjects were collected for comparison.
RESULTS AND CONCLUSION: Three months after treatment, 21 patients presented with reduced pain gait. The spatial-temporal parameters had no difference from normal people at 3 months for treadmill movement of 0° and 6 months for treadmill movement of 15°. At 9 months, kinematic indexes for 15° inclined treadmill movement were consistent with the normal. The findings indicated that BMMSCs for necrosis of the femoral head can recover normal gait mode of the hip in a time-dependent manner.

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