Abstract:

BACKGROUND: Although it has been confirmed in macro and micro level, the pathogenesis of osteoarthritis is still unclear, even self-contradictory and unable to form the more systematic, comprehensive, scientific theory system.
OBJECTIVE: To review the progress in chondrocyte damage following traumatic osteoarthritis and repair mechanism.
METHODS: A computer-based search of CNKI and the PubMed databases from January 1994 to October 2011 was performed for articles related to chondrocyte damage following traumatic osteoarthritis and repair mechanism. The keywords were “osteoarthritis, apoptosis, metalloprotease, free radical” in the title and abstract. Articles related to pathogenesis of traumatic osteoarthritis were selected, and articles published in the same field recently or in authorized journals were preferred. Totally 140 articles were checked, and finally 31 articles addressing periodontal local sustained release agent were reviewed.
RESULTS AND CONCLUSION: Traumatic osteoarthritis occurs based on the macroscopic biomechanical changes, starting with cell transduction mechanism in cellular communication system, which inspires a programmed “destruction and repair” mechanism. Wherein, the chondrocyte apoptosis, catabolic enzymes, free radicals and related cytokine immune response may be the “axial” mechanism of traumatic osteoarthritis.