Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (24): 4530-4534.doi: 10.3969/j.issn.1673-8225.2012.24.033

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Latest research progress of nuclear transcription factor Nrf2

Li Xue-li, Tang Yun, Xu Xue-zhu   

  1. Department of Dermatology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning Province, China
  • Received:2011-10-28 Revised:2011-11-21 Online:2012-06-10 Published:2013-11-05
  • Contact: Xu Xue-zhu, Doctor, Department of Dermatology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning Province, China xuxuezhu@hotmail.com
  • About author:Li Xue-li★, Studying for master?s degree, Department of Dermatology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning Province, China 499812767@qq.com

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Abstract:

BACKGROUND: Nuclear transcription factor Nrf2 belongs to the activated transcription factor family of leucine-zipper. It is related to antioxidant response, anti-inflammatory response and cytoprotection.
OBJECTIVE: To summarize the function of nuclear transcription factor Nrf2 and its relationship with tumor prognosis, antineoplastic property and other diseases of the body system.
METHODS: An online search of PubMed database was performed for articles published between January 1990 and July 2011 with the key word of “Nrf2, Keap1” in English. Articles related to basic research and clinical practice of nuclear transcription factor Nrf2 was included. Obsolete or repetitive articles were excluded. A total of 50 articles were retained in the end.
RESULTS AND CONCLUSION: Nrf2 is not only related to anti-oxidative stress, but to the occurrence, progression and metastasis of tumors. Meanwhile, it is found that Nrf2 is related to many diseases and intoxication in the body system other than oxidative stress-induced disease. Nrf2 inducers may become a potential drug for gene-targeted therapy.

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