Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (25): 4671-4676.doi: 10.3969/j.issn.1673-8225.2012.25.023

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Design of a transdermal delivery system based on STC12C5S60S2 microcontroller

Pan Zhi-xiong1, Yu Xue-fei1, Peng Da-ming2   

  1. 1School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, Guangdong Province, China;
    2Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
  • Received:2011-12-15 Revised:2012-02-23 Online:2012-06-17 Published:2013-11-04
  • Contact: Peng Da-ming, Senior engineer, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China sdzjgd@fimmu.com
  • About author:Pan Zhi-xiong★, Studying master’s degree, School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, Guangdong Province, China Panzhixiong86@ 126.com

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Abstract:

BACKGROUND: Transdermal drug delivery system provides a convenient and effective way for the delivery of peptides and proteins.
OBJECTIVE: To develop a microcontroller-based transdermal drug delivery system, which can provide non-invasive trasdermal drug delivery, maintain the activity of drugs and improve the bioavailability of drugs.
METHODS: The microcontroller was used as the control core. Enhancement techniques such as electroporation, iontophoresis and sonophoresis were added into the delivery of proteins. The skin barrier was overcome at different aspects, and the absorption of transdermal drug was increased. Besides, synergistic effect of these three enhancement techniques was achieved via reasonable design based on software and hardware, as well as the efficiency of drug delivery was improved.
RESULTS AND CONCLUSION: The developed prototype of transdermal drug delivery system was easy to operate. The non-invasive trasdermal drug delivery can improve patients’ compliance and can be used for trasdermal drug delivery with a variety of drugs by adjusting the treatment parameters, as well as provide the potential for individualized therapy.

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