Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (25): 4596-4600.doi: 10.3969/j.issn.1673-8225.2012.25.008

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Antibacterial effects of nano zinc oxide on Candida albicans

He Lin-hai1, Meng Song1, Liu Miao-miao1, Zhou Di-shun1, Li Shan1, Luo Mei2, Ma Xing-ming3, Wang Xue-mei1   

  1. 1School of Stomatology, 3School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China;
    2Department of Stomatology, Anning Branch, General Hospital of Lanzhou Military Area Command of Chinese PLA, Lanzhou 730000, Gansu Province, China
  • Received:2011-12-19 Revised:2012-01-05 Online:2012-06-17 Published:2013-11-04
  • Contact: Wang Xue-mei, Lecturer, School of Stomatology, Lanzhou University, Lanzhou 730000, Gansu Province, China wangxuemei@ lzu.edu.cn
  • About author:He Lin-hai, School of Stomatology, Lanzhou University, Lanzhou 730000, Gansu Province, China Heinhai07@126.com

Abstract:

BACKGROUND: As an inorganic antibacterial agent, nano zinc oxide has different antibacterial mechanisms from organic fungicides.
OBJECTIVE: To explore the antibacterial effects of nano zinc oxide on the fungus, such as Candida albicans.
METHODS: Nano zinc oxide and zinc oxide were prepared as the suspension with concentrations of 100, 75, 50, 25 and 10 g/L respectively. Normal saline served as a negative control. 30 μL suspension with different concentrations was acted on Candida albicans by using Kirby-Bauer disk diffusion method. The culture plate was cultured at a 37 ℃ incubator for 24 hours. The size of inhibition zone was observed and measured.
RESULTS AND CONCLUSION: With the increased concentration of nano zinc oxide, the antibacterial effect on Candida albicans was enhanced gradually, and the diameter of inhibition zone was enhanced. There were no obvious antibacterial effects of zinc oxide on Candida albicans. These findings suggest that nano zinc oxide can inhibit the growth of Candida albicans.

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