Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (46): 8647-8650.doi: 10.3969/j.issn.2095-4344.2012.46.019

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Effect of stress shielding of the Achilles tendon on transforming growth factor beta in rats

Zhao Hua-kun, Yan Xiao-yan, Ma Yan-hong   

  1. Department of Rehabilitation, the Sixth Affiliated People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China
  • Received:2012-01-11 Revised:2012-03-10 Online:2012-11-11 Published:2013-03-16
  • Contact: Ma Yan-hong, Master, Chief physician, Department of Rehabilitation, the Sixth Affiliated People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China
  • About author:Zhao Hua-kun, Studying for master’s degree, Department of Rehabilitation, the Sixth Affiliated People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China zhkmssj@126.com

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Abstract:

BACKGROUND: The changes of cytokines induced by stress shielding in the tendon are closely related to tendon contracture. But the situation of transformation growth factor (TGF)-β remains unclear.
OBJECTIVE: To investigate the effect of stress shielding on TGF-β concentration.
METHODS: Twenty mature male SD rats were randomly divided into model and control groups. Rats in the model group were undergone stress shielding of the Achilles tendon in the left hind limb, and then rose for 2 and 4 weeks. Randomly selected 10 rats’ normal Achilles tendons in the right hind limb served as controls. The levels of TGF-β in the two groups were tested by detection of enzyme-linked immunosorbent assay.
RESULTS AND CONCLUSION: The level of TGF-β in the model group was higher than that in the control groups (P < 0.01). There was no difference between the 2 weeks model group and 4 weeks model group (P > 0.05). These results suggest that after stress shielding of the Achilles tendon for 2 weeks, the level of TGF-β increases obviously and does not decrease at week 4, moreover, the anabolism of tendon is enhanced.

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