Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (47): 8847-8852.doi: 10.3969/j.issn.2095-4344.2012.47.023

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Progress of electrospun nanofiber scaffolds for tissue engineering

Li Jia, Zhou Jia-hua, Xu Qian   

  1. Department of General Surgery, Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu Province, China
  • Received:2012-01-19 Revised:2012-03-02 Online:2012-11-18 Published:2013-03-15
  • Contact: Zhou Jia-hua, Professor, Chief physician, Doctoral supervisor, Department of General Surgery, Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu Province, China zhoujiahua@ hotmail.com
  • About author:Li Jia★, Studying for master’s degree, Department of General Surgery, Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu Province, China ljseu1@163.com

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Abstract:

BACKGROUND: Electrospun nanofiber scaffolds can promote the cell growth.
OBJECTIVE: To describe the effect of electrospun nanofiber scaffolds on the cell growth behavior, and to explore the improvement in the pore size and mechanical strength of electrospun nanofiber scaffolds.
METHODS: The databases of CNKI and PubMed were searched with the key words of “electrospinning, tissue engineering scaffolds, nanofiber” in Chinese and English from 2001 to 2011 to retrieve literature related to electrospinning and tissue engineering scaffolds.
RESULTS AND CONCLUSION: Cell growth behavior is influenced by the properties of electrospun nanofibrous scaffolds, such as fiber diameter, pore size and fiber surface modification. However, inherently small pores of electrospun nanofiber scaffolds do not promote adequate cellular infiltration and tissue growth. Electrospun nanofiber scaffolds have poor mechanical properties. How to increase the pore size of electrospun nanofiber scaffolds to improve cellular infiltration and promote the mechanical strength is an issue for applied research to be addressed.

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