Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (11): 2013-2017.doi: 10.3969/j.issn.1673-8225.2011.11.028

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Plasma monocyte chemoattractant protein 4 and interleukin-8 levels in rabbit deep venous thrombosis 

Fu Zhao-jun, Ren Wei   

  1. Department of Vascular Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing  400016, China
  • Received:2010-11-25 Revised:2011-01-11 Online:2011-03-12 Published:2011-03-12
  • Contact: Ren Wei, Associate professor, Department of Vascular Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China www.renwei9771@ yahoo.com
  • About author:Fu Zhao-jun★, Stufying for master’s degree, Department of Vascular Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China xiangminhuacq@163.com

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Abstract:

BACKGROUND: There are grate individual difference in prognosis of deep venous thrombosis (DVT). Studies have showed that macrophage and endothelial cell play a great part in recanalization.
OBJECTIVE: To study the rabbit plasma monocyte chemoattractant protein 4 (MCP-4) and interleukin-8 (IL-8) levels in different time with DVT, and to observe whether there is specificity in reflection the thrombus.
METHODS: Totally 78 New Zealand rabbits were divided into thrombosis group, sham-surgery group, and normal group. According to the thrombus at 14 days after operation, the thrombosis group was divided into recanalization group and non-recanalization group. The plasma MCP-4 and IL-8 levels were measured and blood routine was performed at 8 hours, 3, 7, and 14 days after operation.
RESULTS AND CONCLUSION: Plasma MCP-4 levels were obviously increased in the recanalization group at 7 days after operation (P < 0.01), but the IL-8 levels were decreased compared with the non-recanalization group (P < 0.05). The variations were not correlated with monocytes or neutrophils (P > 0.05). It is suggested that there is better recanalization results in thrombus that with higher plasma MCP-4. MCP-4 levels can forecast thrombosis prognosis via reflecting activity of macrophage and endothelial cells.

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