Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (47): 8779-8782.doi: 10.3969/j.issn.2095-4344.2012.47.009

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Biological toxicity of resin base containing Ag-TiO2 antibacterial agent

Zhang Cheng-wei2, Liu Jie1, Ge Ya-li2, Wang Han2, Ma Shu-ming1   

  1. 1Department of Denture Production, Stomatology Hospital Affiliated to Jiamusi University, Jiamusi 154002, Heilongjiang Province, China
    2School of Stomatology, Jiamusi University, Jiamusi 154002, Heilongjiang Province, China
  • Received:2012-02-24 Revised:2012-05-04 Online:2012-11-18 Published:2013-03-15
  • Contact: Liu Jie, Doctor, Associate chief physician, Department of Denture Production, Stomatology Hospital Affiliated to Jiamusi University, Jiamusi 154002, Heilongjiang Province, China liujie6363@ yahoo.com.cn
  • About author:Zhang Cheng-wei★, Studying for master’s degree, School of Stomatology, Jiamusi University, Jiamusi 154002, Heilongjiang Province, China zcw_2005@163.com

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Abstract:

BACKGROUND: Nano Ag-TiO2 antibacterial agent is combined with the antibacterial properties of Ag+ and nano TiO2 and widely used in various antibacterial products for its characteristics of broad-spectrum antibiotic, long-lasting effect, high temperature resistance, safety, and economy.
OBJECTIVE: To evaluate the bio-security of resin base containing Ag-TiO2 antibacterial agent on human body.
METHODS: First, oral mucosa irritation test: denture powder containing 0(control), 0.5%,1%,1.5%,2% and 3% Ag-TiO2 antibacterial agents was sutured on the two sides of buccal mucosa of adult golden hamster for 14 days. Then, in vitro toxicity test: Mouse fibroblasts l-929 were seeded on the leaching solution of denture powder containing 0 (control), 0.5%, 1%, 1.5%, 2% and 3% Ag-TiO2 antibacterial agents to culture.
RESULTS AND CONCLUSION: ①Mucous membrane irritating test showed that there was no difference between buccal mucosa contacted with different concentrations of antibacterial resin base and control group of slices. Besides, no allergy or inflammation was found. ②Cytotoxicity test confirmed that various concentrations of Ag-TiO2 antibacterial resin base showed no cytotoxicity, and toxic reaction to level 0. These results suggest that Ag-TiO2 antibacterial resin base conforms to the People’s Republic of China national and relevant pharmaceutical industry standards. It is secure and harmless to human body, moreover, it has good biocompatibility.

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