Chinese Journal of Tissue Engineering Research ›› 2022, Vol. 26 ›› Issue (9): 1329-1333.doi: 10.12307/2022.423

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Effect of splintage and Shenxiaosan cataplasm on fracture healing in rabbits with radial fracture model

Li Rui1,2, Shi Wen3, Yang Shicai4, Lü Linwei1,2, Zhang Chunqiu1,2   

  1. 1Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, 2National Experimental Teaching Demonstration Center of Mechanical and Electrical Engineering, Tianjin University of Technology, Tianjin 300384, China; 3Just Huajian Medical Devices (Tianjin) Co., Ltd., Tianjin 300190, China; 4Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China
  • Received:2021-05-18 Revised:2021-05-19 Accepted:2021-07-14 Online:2022-03-28 Published:2021-12-09
  • Contact: Lü Linwei, Lecturer, Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, and National Experimental Teaching Demonstration Center of Mechanical and Electrical Engineering, Tianjin University of Technology, Tianjin 300384, China
  • About author:Li Rui, Master candidate, Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, and National Experimental Teaching Demonstration Center of Mechanical and Electrical Engineering, Tianjin University of Technology, Tianjin 300384, China
  • Supported by:
    the National Natural Science Foundation of China, No. 12072235 (to ZCQ); Tianjin Natural Science Foundation Project, No. 18JCZDJC36100 (to ZCQ); Science and Technology Major Special Project of Biomedical Engineering of Tianjin Science and Technology Plan Project, No. 18ZXSGSY00010 (to ZCQ)

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Abstract: BACKGROUND: At present, the main clinical methods for the treatment of long bone fractures were external fixation with plaster or splint, and internal fixation such as bone plate or intramedullary nail, simultaneously taking drugs to accelerate fracture healing or applying drugs to the affected area.  
OBJECTIVE: To investigate whether splintage combined with Shenxiaosan cataplasm could improve the rehabilitation of radial shaft fracture.
METHODS:  Eighteen New Zealand white rabbits were used to make a complete fracture model of the left radius, and divided into three groups. No intervention was conducted in the non-intervention group. Models in the splintage group were fixed with splintage. Models in the splintage adjuvant Shenxiaosan group received external fixation with splintage, and adjuvant external application of Shenxiaosan cataplasm (change dressing once a day) (n=6 per group). At 2, 4 and 6 weeks after surgery, the callus position was taken to prepare the sample, and the roughness and particle of callus were measured by atomic force microscope.  
RESULTS AND CONCLUSION: (1) In the splintage group and splintage adjuvant Shenxiaosan group, the rough surface and obvious granular structure of the callus could be clearly observed. These mineral particles were attached to the collagen fibers and presented fish scales. The collagen structure of the splintage adjuvant Shenxiaosan group was much smaller than splintage group. (2) As the healing time increased, the size of bone callus mineral particles gradually decreased. The size of bone mineralization particles in the splintage adjuvant Shenxiaosan group during the same period was 47.5%-69.6% smaller than that of the splintage group. At the same time, as the healing time went on, the roughness of the callus gradually decreased. The roughness of the callus in the splintage adjuvant Shenxiaosan group 2 weeks after the operation was about 69% smaller than that of the splintage group, and the roughness of the callus in the two groups tended to be similar at 6 weeks after the operation. (3) It is indicated that Shenxiaosan cataplasm had a promoting effect on fracture healing.

Key words: Shenxiaosan cataplasm, splintage, fracture healing, atomic force microscope, roughness, granularity

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