Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (50): 9442-.doi: 10.3969/j.issn.1673-8225.2010.50.033

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Expression of estrogen receptor alpha and beta in normal and abnormal tissues

Li Lian-xiang1, Wang Li-guang2, Shen Yu-hua3, Gao Jin-sheng1   

  1. 1 Laboratory of Basic Medical Science, Department of Histology and Embryology, 2 Laboratory of Body Function, Department of Physiology, Medical College of Hebei University of Engineering, Handan  056029, Hebei Province, China; 3Department of Ophthalmology, Third Hospital of Handan, Handan  056002, Hebei Province, China
  • Online:2010-12-10 Published:2010-12-10
  • About author:Li Lian-xiang, Professor, Laboratory of Basic Medical Science, Department of Histology and Embryology, Medical College of Hebei University of Engineering, Handan 056029, Hebei Province, China lianxianglm@ sohu.com
  • Supported by:

    the Key Technology Research & Development Program of Hebei Province, No. 10276105D-3*

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Abstract:

BACKGROUND: As estrogen receptors subtype of β, the signal transduction pathway and mechanism of action of the estrogen receptors α and β are new topics. It has great significant to in-depth research of structure, function of the estrogen receptors α and β as well as its related dependent disease.
OBJECTIVE: To summarize the expression of estrogen receptor α and β in normal and abnormal tissues and its pathophysiology.
METHODS: A computer-based online search of PubMed CNKI databases was undertaken to identify the articles regarding estrogen receptors published between January 2000 and May 2010. Literatures related to structure and function of estrogen receptor α and β, or studies concerning estrogen receptor α and β in normal and abnormal tissues were included. Repetitive studies were excluded.
RESULTS AND CONCLUSION: Totally 38 papers were analyzed according to the inclusive criteria. Estrogen receptor α and β are widely distributed in different tissues with variation in structure and functions, that signal transduction through its receptor influence function of the target, there are differences between the expression ratio and level in normal tissues of different organs and tissues in different diseases, even the tissue cells in different of same organ are different in expression proportion of estrogen receptor α and β.

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