Abstract:

BACKGROUND: Bone morphogenetic proteins (BMPs) can induce bone marrow stromal cells differentiate into osteoblasts or chondrocytes, and inhibit osteoclast activity, which opens up a new way for the treatment of osteoporosis.
OBJECTIVE: To explore an effective means of controlling osteoporosis and make guidance for clinical drug administration and new medicine development by summarizing research progress of BMPs and osteoporosis. 
METHODS: Articles published in CNKI and Pubmed databases were searched by computer with key words of “bone morphogenetic protein, cytokines, bone, osteoporosis” in both Chinese and English from January 1995 and June 2010. Articles in the same circle published in the authoritative journals or recently published were included. Repetitive study or Meta analysis was excluded.
RESULTS AND CONCLUSION: Among 287 articles, 30 were included in the final analysis. BMPs promote bone marrow stromal cells differentiate into osteoblasts, this finding is benefit for reasonable choice for clinical medicine, and effectively prevent osteoporosis. BMPs can obviously promote bone activity, but its mechanism is not entirely clear, there may be more common factors of synergy. The study of mechanism and development provides guidelines for clinical drug application and new medicine development.