Efficacy of absorbable collagen suture for type I and II surgical incisions: a meta-analysis

doi:10.12307/2021.077

Abstract

Abstract:

OBJECTIVE: Absorbable collagen suture has been reported to improve the healing effect for patients with type I and II surgical incisions. However, these studies are single-center small-sample trials, and the results are not clear. This study investigated the efficacy of absorbable collagen suture for type I and II surgical incisions.

METHODS: Databases of PubMed, Web of Science, Cochrane Library, CNKI, Wanfang,and VIP were searched to retrieve the randomized controlled trials concerning the effects of absorbable collagen suture. The modified Jadad scale was used to evaluate the quality of the included research literature. The main outcome indicators were wound healing grades, wound leveling, and wound healing time. The secondary indicators were wound pain, incisional red swelling, and wound bleeding. Meta-analysis was conducted using Stata 16.0 software.

RESULTS: (1) Eleven articles were included, and the median Jadad score was 3.0. There were 1 720 patients, including 887 patients in the trial group and 833 patients in the control group. (2) Meta-analysis results revealed that compared with the control group, in the trial group, incision healing level was improved (RR=1.44, 95%CI:1.02-1.86, P=0.00), and incision flatness was improved (RR=1.11, 95%CI:0.70-1.52, P=0.002); incision healing time was significantly reduced (WMD=-7.44, 95%CI:-8.09 to -6.79, P=0.00); incision pain was significantly reduced (RR=1.95, 95%CI:1.44-2.46, P=0.00); incision bleeding was significantly reduced (RR=-2.63, 95%CI:-4.65 to -0.61, P=0.01); incisional swelling was significantly reduced (RR=-1.00, 95%CI:-1.78 to-0.22, P=0.01).
CONCLUSION: The efficacy of absorbable collagen thread for type I and II surgical incisions was better than that of the silk thread and ordinary absorbable suture.

Key words: biomaterials, collagen, incision, suture, healing, pain, randomized controlled trial, meta-analysis

CLC Number:

Peng Yifan, Wang Chong, Shan Yuanfei, Lu Wenli. Efficacy of absorbable collagen suture for type I and II surgical incisions: a meta-analysis[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(28): 4587-4592.

Figures/Tables 11

References

[1] MCCLEAN ME, BOEN M, ALHADDAD M, et al. Suture lifting: a review of the literature and our experiences. Dermatol Surg. 2020; 46(8):1068-1077.
[2] 时念,郭树忠,苏映军,等.整形外科切口闭合材料的应用进展[J].中国美容整形外科杂志,2018,29(5):310-313.
[3] 王明超,李杰,秦松,等.水产动物源胶原蛋白医学应用研究进展[J].海洋科学, 2018,42(12):109-117.
[4] 胡煜雯.不同可吸收性外科缝线的介绍和降解研究[J].中国医疗器械信息,2019, 25(5):50-51,165.
[5] BYRNE M, ALY A. The surgical suture. Aesthet Surg J. 2019;39(Suppl_2):S67-S72.
[6] 邢惠芝,丁钋.国产胶原蛋白缝线在普外科应用效果分析[J].医疗卫生装备,2014, 35(6):88-89.
[7] 董金辉.普外科国产胶原蛋白缝线的应用效果研究[J].中国医疗器械信息,2017, 23(14):26-27.
[8] 石彦芳.不同可吸收线在乳腺良性包块患者乳腺手术中缝合效果的对比[J].中国现代药物应用,2014,8(24):64-65.
[9] 刘春梅,汪丽萍,胡晓佳.胶原蛋白线在面部整形美容手术中的应用[J].中国美容医学,2009,18(9):1354.
[10] 刘洁.胶原蛋白线与丝线对切口愈合的Meta分析[J].中国医疗美容,2016,6(4):87-90.
[11] ALAM M, RAUF M, ALI S, et al. A systematic review of reporting in randomized controlled trials in Dermatologic Surgery: Jadad scores, power analysis, and sample size determination. Dermatol Surg. 2014; 40(12):1299-1305.
[12] 姜春玲.两种线会阴切口皮内缘缝合临床应用观察[J].齐齐哈尔医学院学报,2008, 29(6):688-688.
[13] 刘峰,贤少忠,张建,等.包皮环切伤口缝合中胶朊蛋白线与普通丝线的疗效对比[J].河北医药,2013,35(20):3141-3142.
[14] 邹向明,韩斌,李婧婷,等.不同可吸收线在乳腺良性包块患者乳腺手术中缝合效果的对比[J].中国老年学杂志,2014, 34(8):2132-2133.
[15] 石红光.120例口腔种植中分别采用可吸收胶原蛋白线与丝线编织非吸收线的效果比较[J].中国医药指南,2014,12(33):16-17.
[16] 徐海洋,徐昊,张丽,等.可吸收胶原蛋白线与丝线编织非吸收线在口腔种植中的应用[J].中国组织工程研究,2014, 18(12):1877-1882.
[17] 陈胜武.可吸收胶原蛋白缝合线在骨科手术缝合中的应用效果观察[J].中国现代药物应用,2016,10(15):275-276.
[18] 周毅波,颜永毅.两种可吸收缝合线在鼻内镜手术中的应用[J].中国耳鼻咽喉头颈外科,2016,23(12):714-715.
[19] 王琼.不同类型的手术缝合线在牙齿种植术中的应用效果对比[J].当代医药论丛,2017,15(13):46-47.
[20] 郭忠华,何永文,何丽明.胶原蛋白线在口腔种植手术切口无张力缝合中的效果及对伤口愈合时间的影响[J].昆明医科大学学报,2018,39(6):52-56.
[21] 杨涌,满孝会.胶原蛋白线一期缝合混合痔创面的临床观察[J].中国医药指南, 2019,17(15):79-80.
[22] 付汉斌,张旭,戴方毅,等.可吸收胶原蛋白线在口腔种植修复术切口无张力缝合中的应用价值[J].中国美容医学,2020, 29(1):97-100.
[23] ZHANG F, XIE Y, CELIK H, et al. Engineering small-caliber vascular grafts from collagen filaments and nanofibers with comparable mechanical properties to native vessels. Biofabrication. 2019;11(3):035020.
[24] 董传民.医用可吸收缝合线创新态势及发展对策研究-基于专利情报的分析[J].科技与创新,2020,(9):73-74,77.
[25] YOUNESI M, DONMEZ BO, ISLAM A, et al. Heparinized collagen sutures for sustained delivery of PDGF-BB: Delivery profile and effects on tendon-derived cells In-Vitro [published correction appears in Acta Biomater]. Acta Biomater. 2016;41:100-109.
[26] RICCI E, CUTTING KF. Evaluating a native collagen matrix dressing in the treatment of chronic wounds of different aetiologies: a case series. J Wound Care. 2016;25(11): 670-678.
[27] KALLIS PJ, FRIEDMAN AJ. Collagen powder in wound healing. J Drugs Dermatol. 2018; 17(4):403-408.
[28] AZMAT CE, COUNCIL M. Wound Closure Techniques. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2020.
[29] Shahidi M. Thrombosis and von willebrand factor. Adv Exp Med Biol. 2017;906: 285-306.
[30] 隋修武,王硕,李瑶,等.胶原蛋白与壳聚糖可吸收缝合线成型的有限元分析与精确纺丝工艺参数控制[J].材料科学与工艺,2017,25(1):84-91.
[31] YOUNESI M, KNAPIK DM, CUMSKY J, et al. Effects of PDGF-BB delivery from heparinized collagen sutures on the healing of lacerated chicken flexor tendon in vivo. Acta Biomater. 2017;63:200-209.