Associations between vitamin D receptor gene polymorphisms and osteoarthritis: a meta-analysis

doi:10.3969/j.issn.2095-4344.2833

Abstract

Abstract:

BACKGROUND: There is a close relationship between vitamin D receptor and osteoarthritis, and vitamin D

receptor gene polymorphism is considered to be able to regulate vitamin D receptor, thus affecting the occurrence of osteoarthritis. However, the existing research is still controversial.

OBJECTIVE: To identify the association between vitamin D receptor gene polymorphism and osteoarthritis.

METHODS: A systematic search was conducted on PubMed, Web of Science, EMbase, Cochrane Library, CBM, CNKI, Wanfang and VIP for studies published from inception to October 2019. All studies that provided vitamin D receptor (ApaI, BsmI, TaqI, and FokI) polymorphism data were retrieved. All statistical analyses were processed using Stata 14.0.

RESULTS AND CONCLUSION: (1) Twenty-one articles involving 7 109 patients were enrolled, including 3 123 patients with osteoarthritis and 4 006 controls (non-osteoarthritis). (2) Meta-analysis results showed that there were associations between vitamin D receptor BsmI polymorphisms and osteoarthritis in the Europe population [(BB vs. bb: OR=1.677, 95% CI(1.051, 2.676), P=0.030; BB vs. Bb+bb: OR=1.780, 95%CI(1.175, 2.697), P=0.007], but there were only three studies. There were associations between vitamin D receptor FokI polymorphism and osteoarthritis in the Asian population [(FF vs. Ff+ff: OR=0.609, 95%CI(0.410, 0.907), P=0.015]. There were only three studies. There was no significant association between vitamin D receptor (TaqI and ApaI) polymorphism and osteoarthritis and no significant correlation between the results after exclusion of heterogeneity. (3) The meta-analysis results suggested that vitamin D receptor (ApaI, BsmI,TaqI and FokI) gene polymorphism might not be significantly correlated with osteoarthritis.

Key words: osteoarthritis, OA, vitamin D receptor, vitamin D receptor gene polymorphism, gene polymorphism, meta-analysis, evidence-based medicine

CLC Number:

Feng Chengqin, Zeng Ping, Luo Jun, Liu Jinfu, Huang Jiaxing. Associations between vitamin D receptor gene polymorphisms and osteoarthritis: a meta-analysis[J]. Chinese Journal of Tissue Engineering Research, 2020, 24(33): 5405-5412.

Figures/Tables 5

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