Autologous chondrocytes combined with collagen I three-dimensional scaffold for treatment of osteochondritis dissecans of the knee

doi:10.3969/j.issn.2095-4344.1415

Abstract

Abstract:

BACKGROUND: Recent studies have shown that autologous chondrocytes combined with collagen I three-dimensional scaffold for treatment of cartilage injury can achieve the clinical efficacy similar to that of normal hyaline cartilage.

OBJECTIVE: To analyze the clinical effect of autologous chondrocytes combined with collagen I three-dimensional scaffold in the treatment of large area (greater than 3.0 cm²) of osteochondritis dissecans of the knee joint.

METHODS: Seven patients with larger area of knee osteochondritis dissecans who received treatment in Shenzhen Pingle Orthopedic Hospital between March 2014 and January 2017. These patients consisted of 4 males and 3 females, aged 21-39 years. The area of osteochondritis dissecans was 3.62-12.51 cm². All patients underwent autologous chondrocytes combined with type I collagen three-dimensional scaffold transplantation and strict rehabilitation training after surgery. The therapeutic effect was evaluated by Lysholm subjective knee score, IKDC score of the International Knee Documentation Committee, pain score, patient satisfaction with treatment and MRI examination before treatment and 3, 9, 12 months after treatment as well as at the last follow up.

RESULTS AND CONCLUSION: All of the seven patients were followed up for 12-24 months and no complications, such as infection and stiffness of joints were observed. The Lysholm subjective knee score and IKDC score at 12 months after treatment and at the last follow up were significantly higher than those before treatment [Lysholm subjective knee score: (92.1±3.3), (93.4±5.2): (54.8±6.4); IKDC: (91.2±3.2), (92.2±3.7), (52.3±6.3), P < 0.05]. There were no significant differences in the Lysholm subjective knee score and IKDC score between 12 months after treatment and the last follow-up (P > 0.05). At 12 months after treatment and at the last follow-up, pain score in seven patients was significantly lower than that before treatment [(1.2±1.5), (0.8±1.1), (6.7±2.2), P < 0.05]. There was no significant difference in pain score between 12 months after treatment and the last follow up (P > 0.05). Six patients were satisfied or very satisfied with the treatment and one patient was not satisfied with the treatment at 12 months after treatment. MRI revealed that at 12 months after treatment, the transplanted cartilage recovered well, with no shedding or local edema. These results suggest that autologous chondrocytes combined with type I collagen three-dimensional scaffold is a safe and effective treatment for osteochondritis dissecans of the knee joint, which can significantly improve the function of affected limb and relieve pain.

Key words: osteochondritis dissecans, autologous chondrocyte, collagen, knee joint, function, pain, three-dimensional scaffold

CLC Number:

Li Zheng, Li Changshu, Lu He, Wang Ping. Autologous chondrocytes combined with collagen I three-dimensional scaffold for treatment of osteochondritis dissecans of the knee[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(30): 4769-4774.

Figures/Tables 3

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