Chinese Journal of Tissue Engineering Research ›› 2013, Vol. 17 ›› Issue (24): 4539-4544.doi: 10.3969/j.issn.2095-4344.2013.24.024

Previous Articles     Next Articles

Effect and mechanism of nestin in the spinal cord development and injury repair process

Wang Shi-yun1, Zhang Ruo-yu2, Liu Xue-hong1   

  1. 1 Medical College of Shaoxing University, Shaoxing  312000, Zhejiang Province, China
    2 Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou  310009, Zhejiang Province, China
  • Received:2012-08-28 Revised:2012-09-28 Online:2013-06-11 Published:2013-06-11
  • Contact: Liu Xue-hong, Associate professor, Medical College of Shaoxing University, Shaoxing 312000, Zhejiang Province, China lxh6588@yahoo.com.cn
  • About author:Wang Shi-yun, Medical College of Shaoxing University, Shaoxing 312000, Zhejiang Province, China 2008wangshiyun@sina.com.cn
  • Supported by:

    the “New Talents Plan” of Universities in Zhejiang Province, No. 2011R426020*; the Science and Technology Plan of Shaoxing City, No. 2009A33025*; the Science and Technology Plan of Zhejiang Province, No. 2012C33066*; the National Natural Science Foundation of China, No. 81100241*

PDF

529

Abstract:

BACKGROUND: As a specific marker of neurons, expression activity of Nestin to a certain extent reflects the evolution law of spinal cord nerve cells’s proliferation, differentiation and migration.
OBJECTIVE: To review the molecular structure, biological function, and expression and distribution law of Nestin in spinal cord development and damage repair, then to provide previous research foundation in the transplantation of neural stem cells after spinal cord injury.
METHODS: VIP and Wanfang databases (1990/2012) were retrieved by computer with the key words of “spinal cord, Nestin” in Chinese. At the same time, PubMed, Springer and e-book (full text) databases (1990/2012) were retrieved with the key words of “spinal cord, Nestin” in English. Totally 343 articles were retrieved, and finally 35 articles were included.
RESULTS AND CONCLUSION: As a specific marker of neural stem cells, Nestin at embryo stage shows a space-time expression that has a inverse relationship with the mature degree of neural precursor cells, namely with neural cell differentiation and growth continued to mature, Nestin expression strength would gradually abate, and even disappear. And in spinal cord injury pathological situations, Nestin expression strength and quantity in damaged tissue zone also reflect the repair ability of damaged spinal cord tissues. So during the development of spinal cord tissues, Nestin expression strength, quantity and distribution is now an important index for judging the development of spinal cord nerve cells, which can provide significant preliminary basis for research work for clinical treatment of spinal cord injury.

Key words: tissue construction, tissue construction review, spinal cord, nestin, spinal cord injury, development, injury, repair, neurons, spinal cord neurons, markers, National Natural Science Foundation of China

CLC Number: