Effect of different intensities of aerobic exercises on rat liver cells

doi:10.3969/j.issn.2095-4344.2015.51.020

Abstract

Abstract:

BACKGROUND: A large number of experimental studies have shown that different exercise intensities can easily lead to liver injury in rats, thereby resulting in apoptosis. However, the mechanism is still unclear.
OBJECTIVE: To investigate the effects of different intensity exercise on the morphology and function of rat liver cells in order to provide some theoretical support for alleviating and preventing sports-induced diseases.
METHODS: A computer-based online search of CNKI database, PubMed database and VIP database was performed to search related articles with the keywords of “exercise intensity; hepatocytes; apoptosis; apoptosis detection” in Chinese and English, respectively. The literatures related to the effects of different intensity of aerobic exercise on the liver cells of rats were selected. Articles published in the authoritative journals in the same field were preferred. Totally 44 literatures were analyzed.
RESULTS AND CONCLUSION: Acute exhaustive exercise can damage the liver cells of rats. Large intensity motion initiates rat liver cell apoptosis, due to the imbalance between the formation and elimination of free

radicals and the reduced capacity of the calcium uptake by sarcoplasmic reticulum. Because of the difficulty in determination of load capacity, however, it is difficult to study and more experiments are needed. Under moderate intensity exercise, the liver tissues exhibit adaptive changes that the damage is weakened and the body tends to recovery. Increasing intensity of exercise and hypoxia both cause damage to the liver tissue and function in rats. These findings indicate that different intensities of aerobic exercise can lead to changes in the structure and function of rat liver cells to different extents, suggesting that the principle of exercise training should be followed to alleviate exercise fatigue and prevent sports-induced diseases.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

CLC Number:

R318

Yuan Hai-yan, Hu Ya-zhe. Effect of different intensities of aerobic exercises on rat liver cells[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(51): 8311-8316.

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