Expression of transforming growth factor beta3 in meniscus development

doi:10.3969/j.issn.2095-4344.2015.33.006

Abstract

Abstract:

BACKGROUND: Since the meniscal blood supply is only in the red zone, the synovial fluid becomes the main nutrition source of the meniscus. As its poor self-healing ability, the meniscus is almost impossible to heal in non-blood supply regions.
OBJECTIVE: To investigate the expression and characteristics of transforming growth factor-β3 in the rat meniscus during postnatal development.
METHODS: Meniscus tissues of Wistar rats with different ages (1, 7, 14, 21, 28, 35 days) were adopted, and immunohistochemistry and RT-PCR methods were performed to detect the location and expression pattern of transforming growth factor-β3 within the meniscus.
RESULTS AND CONCLUSION: Immunohistochemistry results revealed that the expression of transforming growth factor-β3 started from the joint capsule, and gradually extended to the red zone, gray zone, and white area; RT-PCR results showed the mRNA expression of transforming growth factor-β3 in the rat meniscus at different ages, and during development process gradually increased until adult stage (rat weight > 100 g), which remained relatively stable.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Transforming Growth Factor beta3, Menisci, Tibial, Knee Joint

CLC Number:

R318

Wang Jian, Sun Yu, Bai Xi-zhuang. Expression of transforming growth factor beta3 in meniscus development[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(33): 5274-5278.

Figures/Tables 4

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